Results 211 to 220 of about 4,033,045 (310)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Multi-layer gut microbiome variation in type 2 diabetes despite preserved higher-order community structure. [PDF]

Front Microbiol
Zhou J, Du P, Liu L, Wang L, Liu S, Yan G.   +5 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Mechanically Durable Intrinsically Stretchable Neuromorphic Devices via Molecular Microstructure Design. [PDF]

Small
Kim KN, Baek HE, Choi MJ, Sung MJ, Lee SW, Song CY, Lee HH, Ma S, Ayu Larasati K, Sun JY, Park HL, Kim YH, Lee TW.   +12 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Telomere-to-telomere genome assembly and a pangenome for the rat. [PDF]

Cell Genom
Li K, Ciosek JL, Koren S, Phillippy AM, Zhu Y, Lauer WA, Brooks SY, Bouffard GG, Pickett BD, Dumont BL, Smith ML, Kalbfleisch TS, Doris PA.   +12 more
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Occurrence and Distribution Profiles of Perfluoroalkyl and Polyfluoroalkyl Substances in Water and Sediment of the Lower Reaches of the Yellow River. [PDF]

Water Environ Res
Xiaodong X, Ke G, Lan M, Hong L, Hong Z, Mingquan W, Ruibao J.   +6 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

eDNA-based assessment of microbial dynamics in response to persistent contaminants and degraded water quality in a hypereutrophic urban reservoir. [PDF]

Environ Monit Assess
Pimentel JSM, Starling MCVM, Amorim CC, Viana VFL, Martins AS, Rodrigues DAS, Brandão LPM, de Jonge N, Jørgensen NOG, Schlüter L, Simcik M, Nielsen JL.   +11 more
europepmc   +1 more source