Too packed to change: side-chain packing and site-specific substitution rates in protein evolution [PDF]
In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density.
María Laura Marcos, Julian Echave
doaj +2 more sources
The strategic integration of agile and lean supply [PDF]
Lean supply is closely associated with enabling flow and the elimination of wasteful variation within the supply chain. However, lean operations depend on level scheduling and the growing need to accommodate variety and demand uncertainty has resulted in
Christopher +19 more
core +1 more source
Investigation of dynamic influences in tilted-wave interferometry [PDF]
Aspherical and freeform lenses allow for compact optical systems and have therefore gained high interest in optics. The interferometric measurement of these forms is a challenge, for which the tilted-wave interferometer (TWI) has been developed.
Scholz Gregor +2 more
doaj +1 more source
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias [PDF]
Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates.
Aoki, Junken +9 more
core +3 more sources
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-protein diets are recapitulated by specifically reducing dietary levels of the three branched-chain amino acids (BCAAs), leucine, isoleucine, and valine.
Deyang Yu +26 more
semanticscholar +1 more source
Variational collision integrator for polymer chains [PDF]
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Leyendecker, Sigrid +2 more
openaire +1 more source
Markov chain Monte Carlo enhanced variational quantum algorithms
Abstract Variational quantum algorithms have the potential for significant impact on high-dimensional optimization, with applications in classical combinatorics, quantum chemistry, and condensed matter. Nevertheless, the optimization landscape of these algorithms is generally nonconvex, leading the algorithms to converge to local, rather
Taylor L Patti +3 more
openaire +2 more sources
Energy Supply Chain Optimization Under Demand Variation and Emission Constraints
preview not available - see full-text PDF article.
V. Bounovas +3 more
doaj +1 more source
Mercury (Hg) biomagnification in fish food chains is a relevant subject due to the high fish consumption of the Amazonian population and the high toxicity of this metal.
Lucas Silva Azevedo +5 more
doaj +1 more source
Robustness of large-scale stochastic matrices to localized perturbations [PDF]
Upper bounds are derived on the total variation distance between the invariant distributions of two stochastic matrices differing on a subset W of rows.
Como, Giacomo, Fagnani, Fabio
core +2 more sources

