Results 111 to 120 of about 2,894,137 (337)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
DIAGNOSIS OF CUCUMBER PLANT DISEASES USING CERTAINTY FACTOR AND FORWARD CHAINING METHODS
Techno Nusa Mandiri: Journal of Computing and Information TechnologyCucumber plants spread and can live in tropical climates like Indonesia. The cucumber plant has many benefits and can be a beauty ingredient. Cucumbers, like other plants, can also have disease attacks, which can threaten farmers.
Bligania Bligania +4 more
doaj +1 more source
Deductive databases and P systems [PDF]
Computer Science Journal of Moldova, 2004 In computational processes based on backwards chaining, a rule of the type is seen as a procedure which points that the problem can be split into the problems. In classical devices, the subproblems are solved sequentially.
Miguel A. Gutierrez-Naranjo +1 more
doaj
Overshoot in biological systems modelled by Markov chains: a non‐equilibrium dynamic phenomenon [PDF]
, 2014 Chen Jia, Minping Qian, Daquan Jiang
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Dynamical phase transition in the simplest molecular chain model [PDF]
, 2014 V. A. Malyshev, S. A. Muzychka
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Quantum chemical calculations of geometries and gas-phase deprotonation energies of linear polyyne chains [PDF]
, 2001 U. M�lder +2 more
openalex +1 more source