Results 131 to 140 of about 2,894,137 (337)
Cultural adaptation in Chinese‐Western supply chain partnerships
, 2013 Fu Jia, Richard Lamming
openalex +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Calmodulin and myosin light-chain kinase of rabbit fast skeletal muscle [PDF]
, 1979 Angus C. Nairn, S V Perry
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A multi-period risk sharing supply chain contract under consideration of price and demand uncertainties [PDF]
, 2021 Isil Tari
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Axonemal dynein light chain-1 locates at the microtubule-binding domain of the γ heavy chain
, 2015 Muneyoshi Ichikawa +10 more
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Tracing the Supply Chain of Medicinal Wild Yam Species (Dioscorea spp.) in Cundinamarca, Colombia [PDF]
, 2022 Darío Pérez, Lauren Raz
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source