Results 291 to 300 of about 53,724 (334)

Stereoselectivity of chalcone isomerase with chalcone derivatives: a computational study

Journal of Molecular Modeling, 2013
Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcones into flavonoids. The activity of CHI is essential for the biosynthesis of flavonoids precursors of floral pigments and phenylpropanoid plant defense compounds. In the present study, we explored the detailed binding structures and binding free energies for two different ...
Yuan Yao, Hui Zhang, Ze-Sheng Li, Ze-Sheng Li   +3 more
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Anticancer activities of novel chalcone and bis-chalcone derivatives

Bioorganic & Medicinal Chemistry, 2006
A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A.
Peng Huang, Nancy E. Davidson, Saeed R. Khan, Aneta Modzelewska, Catherine Pettit, Geetha Achanta   +5 more
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Epoxidation of chalcones

Chemistry of Heterocyclic Compounds, 1971
Previously undescribed aromatic α-keto oxides have been obtained by the epoxidation of chalcones with alkaline hydrogen peroxide in methanolic solution.
V. F. Belyaev, N. M. Yatsevich
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The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity

Mini-Reviews in Medicinal Chemistry, 2021
Quinazoline and/or chalcones derivatives are important targets in several areas of chemical sciences, mainly, in the medicinal chemistry and pharmaceutical research. The purpose of this review was to systematize the information available in the literature, including patents, regarding the benefits, exerted by the combination of these two ...
Dennis Russowsky, Eduardo Bustos Mass, Gilmar Vieira Duarte   +2 more
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Anti‐tumorigenic chalcones [PDF]

STEM CELLS, 1994
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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Direct antibacterial and antibiotic resistance modulatory activity of chalcones synthesized from the natural product 2-hydroxy-3,4,6-trimethoxyacetophenone.

FEMS Microbiology Letters, 2020
Antibiotic for clinical use lose its effectiveness over time due to bacterial resistance. In this work, four chalcones with modifications in their ligands were synthesized from the natural product 2-hydroxy-3,4,6-trimethoxyacetophenone, characterized by ...
T. S. Freitas, J. C. Xavier, R. L. Pereira, J. Rocha, Dédora F Muniz, P. T. da Silva, João P da Hora, Hélcio S dos Santos, P. Bandeira, C. Nogueira, A. Teixeira, H. Coutinho   +11 more
semanticscholar   +1 more source

Chemical sensing of chalcones by voltammetry: trans-Chalcone, cardamonin and xanthohumol

Electrochimica Acta, 2013
Abstract Xanthohumol (XN) and cardamonin (CD) belong to the chemical class of chalcones which are phenolic compounds of large interest due to their health promoting properties. In the present work, their electrochemical behavior on a hanging mercury drop electrode (HMDE) is compared to trans -chalcone by means of cyclic voltammetry (CV).
Tavares, E.M., Carvalho, A.M., Gonçalves, Luis M., Valente, I.M., Moreira, M.M., Guido, L.F., Rodrigues, J.A., Doneux, Thomas, Barros, Aquiles   +8 more
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Chalcones: As potent α-amylase enzyme inhibitors; synthesis, in vitro, and in silico studies.

Medicinal chemistry, 2020
BACKGROUND The inhibition of α-amylase enzyme is one of the best therapeutic approach for the management of type II diabetes mellitus. Chalcone possesses a wide range of biological activities.
Mahboob Ali, Momin Khan, K. Zaman, A. Wadood, M. Iqbal, A. Alam, Sana Shah, A. Rehman, M. Yousaf, R. Rafique, K. Khan   +10 more
semanticscholar   +1 more source

Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.

Journal of Natural Products, 2020
Activating mutations in FLT3 receptor tyrosine kinase are found in a third of acute myeloid leukemia (AML) patients and are associated with disease relapse and a poor prognosis.
H. Malik, Aishah Bilal, Rahim Ullah, Maheen Iqbal, Sardraz Khan, Ishtiaq Ahmed, K. Krohn, R. Saleem, H. Hussain, A. Faisal   +9 more
semanticscholar   +1 more source

Recent developments in biological aspects of chalcones: the odyssey continues

Expert Opinion on Drug Discovery, 2019
Introduction: Chalcones are attractive to synthetic chemists because they are easy to prepare, have a large number of replaceable hydrogens, thereby having significant biological potential.
A. Rani, A. Anand, K. Kumar, Vipan Kumar
semanticscholar   +1 more source