Results 331 to 340 of about 54,606 (348)

Chalcone hybrids and their antimalarial activity

Archiv der Pharmazie, 2020
AbstractMalaria, one of the most striking, re‐emerging infectious diseases caused by the genus Plasmodium, places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug‐resistant malaria, creating an urgent need to develop novel antimalarial ...
Peng Cheng, Linlin Yang, Xiaodan Huang, Xuejun Wang, Maoqing Gong   +4 more
openaire   +3 more sources

Potent and highly selective dual‐targeting monoamine oxidase‐B inhibitors: Fluorinated chalcones of morpholine versus imidazole

Archiv der Pharmazie, 2019
Two series of fluorinated chalcones containing morpholine and imidazole‐based compounds (f1–f8) were synthesized and evaluated for recombinant human monoamine oxidase (MAO)‐A and ‐B as well as acetylcholinesterase inhibitory activities.
B. Mathew, S. Baek, D. G. Thomas Parambi, J. P. Lee, G. E. Mathew, S. Jayanthi, Devaraji Vinod, Clariya Rapheal, Vinod Devikrishna, Shahin Shad Kondarath, M. Uddin, Hoon Kim   +11 more
semanticscholar   +1 more source

The retroaldol reaction of chalcone

Canadian Journal of Chemistry, 1983
All four rate constants required to describe the hydration and aldolization/dealdolization reactions of chalcone (1,3-diphenyl-2-propen-1-one) have been determined in aqueous sodium hydroxide solutions. Kinetics were studied starting with chalcone, with its hydrate, 1,3-diphenyl-3-hydroxy-1-propanone, and with benzaldehyde in the presence of excess ...
Nayyer Monshizadeh Kamkar, Kathleen F. Taylor, John Cossar, J. Peter Guthrie, Patricia A. Cullimore   +4 more
openaire   +2 more sources

Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer.

Anti-Cancer Agents in Medicinal Chemistry, 2019
BACKGROUND Chalcones are naturally occurring compounds found in various plant species which are widely used for traditional popular treatments. Chalcones are distinguished secondary metabolites that are reported to display diverse biological activities ...
M. Tantawy, Farid M Sroor, Magda F. Mohamed, M. El-Naggar, Fatma M. Saleh, H. Hassaneen, Ismail A. Abdelhamid   +6 more
semanticscholar   +1 more source

Polymorphism and conformerism in chalcones

CrystEngComm, 2016
Herein two solid state phenomena have been observed in two chalcones. Firstly, polymorphism has been found in (E)-1-(2-aminophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (1). This compound crystallizes with only one conformer rather than three in the known reported structure. In the polymorphs, the conformation of the phenyl ring bonded to carbonyl
Felipe T. Martins, Freddy Fernandes Guimarães, Rafael Rodrigues Ramos, Cameron Capeletti da Silva   +3 more
openaire   +2 more sources

Photochemical Behavior of Chalcone and the Photo-Alignment of Liquid Crystal with Chalcone Derivatives

Molecular Crystals and Liquid Crystals, 2002
The photoisomerization behavior of benzylidene-acetophenones known as chalcones, was studied. We synthesized the chalcone derivatives that have ether groups at 4 and 4′ positions. Due to the electron donating ability of the ether oxygen, the bond order of the single bond between two phenyl ring of the chalcone strengthened, which eventually increased ...
Kyung-Hoon Jung, Dong-Myung Shin, Dong-Mee Song   +2 more
openaire   +2 more sources

Inhibiting Firefly Bioluminescence by Chalcones

Analytical Chemistry, 2017
Chalcone refers to an aromatic ketone and an enone that constitutes the central core for various important biological compounds in drug discovery. Moreover, the firefly luciferase (Fluc) as the bioluminescent reporter has been widely used in life science research and high-throughput screening (HTS).
Huateng Zhang, Jing Su, Yuxin Lin, Haixiu Bai, Jiaxiang Liu, Hui Chen, Lupei Du, Lichuan Gu, Minyong Li   +8 more
openaire   +3 more sources

Perspective design of chalcones for the management of CNS disorders: A mini-review.

CNS and Neurological Disorders - Drug Targets, 2019
The development of chalcone based compounds for CNS disorders have been explored by many research groups. Chalcones are being considered as a potent organic scaffold with wide spread applications in the field of drug discovery and medicinal chemistry ...
B. Mathew, D. G. Parambi, Vishnu Sankar Sivasankarapillai, J. Suresh, G. E. Mathew, Monu Joy, A. Marathakam, Sheeba Varghese Gupta   +7 more
semanticscholar   +1 more source

Structural study on chalcone derivatives

Synthetic Metals, 1994
Abstract Crystal structures of several SHG-active chalcone derivatives were determined by X-ray analysis. The phase-matching direction of a 1-(3-thienyl)-3-(4-chlorophenyl)-2-propen-1-one crystal is discussed by relating to its molecular packing in the crystal.
K. Kozawa, Y. Kimura, Y. Goto, Tokiko Uchida   +3 more
openaire   +2 more sources

The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity

Drug and chemical toxicology (New York, N.Y. 1978), 2018
Carbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses.
Hatice Esra Aslan, Yeliz Demir, M. S. Özaslan, F. Türkan, Ş. Beydemir, Ö. Küfrevioğlu   +5 more
semanticscholar   +1 more source