Results 81 to 90 of about 2,443,514 (252)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Discover OceansA new record of trapeziid crab Sphenomerides trapezioides (Wood-Mason in Wood-Mason & Alcock, 1891) is reported from the seamounts of the Lakshadweep Sea, Northern Indian Ocean. Specimens were collected from deep-sea exploratory surveys conducted by FORV
Raveendhiran Ravinesh +2 more
doaj +1 more source
Arthur Conan Doyle’s Quest Journey to The Land of Mist
Akademisk Kvarter, 2012 Arthur Conan Doyle employed the quest narrative structure in his Professor Challenger novels and short stories. The themes that were embodied in the journey were imperialism, positivist science, the male role, evolution, degeneration and atavism ...
Jørgen Riber Christensen
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A coupled phosphorus and carbon cycling mediated by prokaryotic microbes in the deepest trench
Frontiers in Marine ScienceThere has been a long-standing paradox in oceanic phosphorus (P) cycling in the ocean: high alkaline phosphatase activity (APA) persists in deep waters despite replete dissolved inorganic phosphorus (DIP), and active microbial regulatory mechanisms ...
Tianqiang Bao +13 more
doaj +1 more source
The Weekly Challenger, September 28, 2023
, 2023 The September 28, 2023, issue of The Weekly Challenger.https://digitalcommons.usf.edu/challenger/2342/thumbnail ...
The Weekly Challenger, et al
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
AgronomyDiseases of tomato leaves can seriously damage crop yield and financial rewards. The timely and accurate detection of tomato diseases is a major challenge in agriculture. Hence, the early and accurate diagnosis of tomato diseases is crucial.
Zhichao Chen +3 more
doaj +1 more source