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Fibrolamellar carcinoma: Challenging the challenge

European Journal of Cancer, 2020
Fibrolamellar carcinoma (FLC) is a rare and poorly understood malignancy, which seems to be more prevalent in young patients compared with conventional hepatocellular carcinoma (HCC). Performing prospective clinical trials recruiting patients diagnosed with FLC has proven challenging with scarce data available guiding clinical management.
Angela Lamarca   +7 more
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The Challenges of Challenge Experiments

New England Journal of Medicine, 2014
Challenge experiments involving infecting healthy human subjects to test the efficacy of a new vaccine can be invaluable, but historically, researchers sometimes undertook such efforts with little attention to ethical concerns raised by purposefully making people sick.
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Challenges

ACM SIGART Bulletin, 1983
It is the intent of this article to push beyond the horizon of "current survey and future work," with a set of mildly outrageous long-term challenges. The targeted areas are expert systems, problem solving and learning. Somewhere between AAAI-82 and science fiction, our future research projects lie.
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The challenge of recommender systems challenges

Proceedings of the sixth ACM conference on Recommender systems, 2012
Recommender System Challenges such as the Netflix Prize, KDD Cup, etc. have contributed vastly to the development and adoptability of recommender systems. Each year a number of challenges or contests are organized covering different aspects of recommendation. In this tutorial and panel, we present some of the factors involved in successfully organizing
Alan Said, Domonkos Tikk, Andreas Hotho
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Challenging the Glucose Challenge Test

Obstetrical & Gynecological Survey, 2011
To reduce the number of patients needing oral glucose tolerance test (OGTT), screening options have been considered, balancing patient comfort, cost and risk of missed diagnosis. Australian Diabetes in Pregnancy Society (ADIPS) recommends glucose challenge test (GCT) as screening for gestational diabetes mellitus (GDM), while others suggest fasting ...
Jenny, Huynh   +4 more
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Challenges to IS quality

Information and Software Technology, 1997
Investing in quality was popular in the early 1990s. Several approaches were developed, but it seems that none of them provides a solution that is generally accepted and adequately detailed for both scientific and practical purposes within the IS field.
Tomi Dahlberg, Janne Järvinen
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To challenge or not to challenge?

Significance
Abstract In any sport, challenging a referee's decision is risky. The challenge process in American football is particularly chaotic, and coaches have just precious seconds in which to decide whether to throw the red challenge flag and gamble their team's fortunes. Can statistics help them?
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The Challenge of Peremptory Challenges

Journal of Law, Economics, and Organization, 1996
The criminal jury system is characterized by two often conflicting features: (1) A very diverse population, like that in the United States, is likely to result in even rational, open-minded jurors disagreeing about issues fundamental to the resolution of any case, and (2) almost all jurisdictions require unanimity in order to either acquit or convict a
E. P. Schwartz, W. F. Schwartz
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Challenge, What Challenge?

1990
There are two inter-related aims in this final chapter. First, to evaluate some of the foregoing material under the headings of strengths, weaknesses and challenges. Second, to restate and summarise some of the judgements made in the previous chapters.
Jean-Louis Barsoux, Peter Lawrence
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