Results 131 to 140 of about 4,254,908 (281)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
MAQUIAVELO: LA LEGALIZACIÓN DEL AZAR AL SERVICIO DE LA REPÚBLICA FLORENTINA
DaimonA partir de la elucidación de los influjos cristianos sobre el pensamiento político de Nicolas Maquiavelo, la autora rastrea el fondo epistemológico que subyace a sus propuestas, consistente en la transformación del azar, con el que se identificaba la ...
Carmen Hidalgo Roldán
doaj
Measurement of H2O and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 km [PDF]
Data analysis results from the 1983 BIC 1 and 2 balloon flights are presented, with emphasis on H2O2, OH, HCL, O3, O2, and H2O. A 2 sigma limit on H2O2 abundance was set, as a function of altitude.
Chance, K. V., Traub, W. A.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Stoch-aptation: a new term in the science of evolution
Ideas in Ecology and Evolution, 2015 Following two seminal papers published in Paleobiology by Stephen Jay Gould and Elisabeth Vrba several decades ago, I suggest a new term (stoch-aptation) to refer to those individual traits or sets of traits that provide, just by chance, fitness ...
Alejandro Martínez Abraín
doaj
July 3, 2013 Reflection: A Chance Encounter
, 2013 In a July 4 letter to his father-in-law, General Alexander Hays expressed reserve. “Yesterday was a warm one for us,” he wrote. “The fight of my division was a perfect success […] We are all sanguine of ridding our soil of the invaders.” The “perfect ...
Isherwood, Ian A.
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source