Results 131 to 140 of about 4,276,422 (291)
ARİSTOTELES VE FARABİ'NİN FELSEFESİNDE RASTLANTININ YERİ
Felsefe Dünyası, 2005 İsmail ERDOĞAN, ARİSTOTELES VE FARABİ'NİN FELSEFESİNDE RASTLANTININ ...
İsmail Erdoğan
doaj
July 3, 2013 Reflection: A Chance Encounter
, 2013 In a July 4 letter to his father-in-law, General Alexander Hays expressed reserve. “Yesterday was a warm one for us,” he wrote. “The fight of my division was a perfect success […] We are all sanguine of ridding our soil of the invaders.” The “perfect ...
Isherwood, Ian A.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Stoch-aptation: a new term in the science of evolution
Ideas in Ecology and Evolution, 2015 Following two seminal papers published in Paleobiology by Stephen Jay Gould and Elisabeth Vrba several decades ago, I suggest a new term (stoch-aptation) to refer to those individual traits or sets of traits that provide, just by chance, fitness ...
Alejandro Martínez Abraín
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source