Results 261 to 270 of about 4,304,349 (326)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Decoding the Self: Single-Trial Prediction of Self-Boundary Meditation States From Magnetoencephalography Recordings. [PDF]
Röhr H +8 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Coefficient Lambda for Interrater Agreement Among Multiple Raters: Correction for Category Prevalence. [PDF]
Almehrizi RS.
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Tolman's Sunburst Maze 80 Years on: A Meta-Analysis Reveals Poor Replicability and Little Evidence for Shortcutting. [PDF]
Duvelle É, Grieves RM.
europepmc +1 more source
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The ability to divide spatial attention across non-contiguous locations develops in middle childhood. [PDF]
Blankenship TL, Strong R, Kibbe MM.
europepmc +1 more source
Modeling Flexible Generator Operating Regions via Chance-constrained Stochastic Unit Commitment.
Bismark Singh
openalex +1 more source

