Results 101 to 110 of about 775 (133)

Neuroinvasion by Chandipura virus

Acta Tropica, 2014
Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invade the central nervous system (CNS ...
Jyoti Rana, Sreejith Rajasekharan, Sahil Gulati   +2 more
exaly   +3 more sources

Ribavirin inhibits Chandipura virus replication in Vero cells

Journal of Medical Virology, 2020
AbstractChandipura virus (CHPV) is an emerging tropical pathogen in India. The virus has been reported to be associated with an acute encephalitis syndrome in young children with a case fatality rate of 55% to 75%. Clinical management with symptomatic treatment is the only option available to treat infected patients.
Anukumar Balakrishnan
exaly   +3 more sources

Host interactions of Chandipura virus matrix protein

Acta Tropica, 2015
The rhabdovirus matrix (M) protein is a multifunctional virion protein that plays major role in virus assembly and budding, virus-induced inhibition of host gene expression and cytopathic effects observed in infected cells. The myriad roles played by this protein in the virus biology make it a critical player in viral pathogenesis.
Kapila Kumar, Jyoti Rana, Sreejith Rajasekharan   +2 more
exaly   +3 more sources

Biological and Pathogenic Blueprint of Chandipura Virus

Reviews in Medical Virology
ABSTRACT Chandipura virus (CHPV) is a single‐stranded negative‐sense RNA virus of the family Rhabdoviridae . CHPV is transmitted mainly through infected sandflies. CHPV paediatric encephalitis reported in 2003–2004 in central and south‐western parts of India had a case ...
Sunit K Singh, Neha Pandey
exaly   +3 more sources

Intraviral protein interactions of Chandipura virus

Archives of Virology, 2012
Chandipura virus (CHPV) is an emerging rhabdovirus responsible for several outbreaks of fatal encephalitis among children in India. The characteristic structure of the virus is a result of extensive and specific interplay among its five encoded proteins.
Kapila, Kumar, Jyoti, Rana, R, Sreejith, Reema, Gabrani, Sanjeev K, Sharma, Amita, Gupta, Vijay K, Chaudhary, Sanjay, Gupta   +7 more
openaire   +2 more sources

Chandipura Virus: An emerging tropical pathogen

Acta Tropica, 2012
Chandipura Virus (CHPV), a member of Rhabdoviridae, is responsible for an explosive outbreak in rural areas of India. It affects mostly children and is characterized by influenza-like illness and neurologic dysfunctions. It is transmitted by vectors such as mosquitoes, ticks and sand flies.
Sunil, Menghani, Rupesh, Chikhale, Ami, Raval, Pankaj, Wadibhasme, Pramod, Khedekar   +4 more
openaire   +2 more sources

Structure and expression of the glycoprotein gene of chandipura virus

Virology, 1989
A cDNA copy of the mRNA for the glycoprotein G of Chandipura virus, a rhabdovirus, has been cloned, sequenced, and expressed in mammalian cells. The deduced amino acid sequence of G shows that the encoded protein is a typical transmembrane glycoprotein of 524 amino acids containing a cleavable amino-terminal signal peptide, two potential N-linked ...
P S, Masters, R S, Bhella, M, Butcher, B, Patel, H P, Ghosh, A K, Banerjee   +5 more
openaire   +2 more sources

A brief overview of Chandipura virus

International Journal of Research in Pharmacology & Pharmacotherapeutics
Chandipura Virus (CHPV), part of the Rhabdoviridae family, causes outbreaks primarily in rural India, affecting children with influenza-like symptoms and neurological issues. Transmitted by vectors like mosquitoes, ticks, and sand flies, CHPV has a negative-sense RNA genome encoding five proteins (N, P, M, G, L).
Dr. Kiran G, M. Pravallika, Sk. Sameena, K. Pradeep   +3 more
openaire   +1 more source

VENEREAL TRANSMISSION OF CHANDIPURA VIRUS BY PHLEBOTOMUS PAPATASI (SCOPOLI)

The American Journal of Tropical Medicine and Hygiene, 2006
Experiments were conducted in the laboratory on Phlebotomus papatasi to determine the possible role of males in maintaining or sustaining the Chandipura virus (CHPV) activity in nature. This study indicated that infected males are capable of passing on the virus to female sand flies while mating.
M S, Mavale, P V, Fulmali, G, Geevarghese, V A, Arankalle, Y S, Ghodke, P C, Kanojia, A C, Mishra   +6 more
openaire   +2 more sources

Lycorine Inhibits Chandipura Virus Replication In Vitro

Journal of Medical Virology
ABSTRACT Chandipura virus (CHPV), a neurotropic member of the Rhabdoviridae family, causes severe paediatric encephalitis outbreaks in India with high fatality rates and no approved antiviral therapies. In this study, lycorine, a plant‐derived alkaloid with established broad‐spectrum antiviral activity, was evaluated for its efficacy ...
Tanvi Agrawal, Shikha Singh, Gurleen Kaur, Shiva Rathore, Harshita Sharma, Gunjan Rajput, Sweety Samal, Amit Awasthi   +7 more
openaire   +2 more sources