Results 51 to 60 of about 775 (133)

Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. [PDF]

PLoS Neglected Tropical Diseases, 2013
Japanese encephalitis virus (JEV) is a major cause of viral encephalitis in South and South-East Asia. Lack of antivirals and non-availability of affordable vaccines in these endemic areas are a major setback in combating JEV and other closely related ...
V Haridas, Kullampalayam Shanmugam Rajgokul, Sandhya Sadanandan, Tanvi Agrawal, Vats Sharvani, M V S Gopalakrishna, M B Bijesh, Kanhaiya Lal Kumawat, Anirban Basu, Guruprasad R Medigeshi   +9 more
doaj   +1 more source

Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death

mBio, 2021
Poliomyelitis-like illness is a common clinical manifestation of neurotropic viral infections. Functional loss and death of motor neurons often lead to reduced muscle tone and paralysis, causing persistent motor sequelae among disease survivors.
Meenakshi Bhaskar, Sriparna Mukherjee, Anirban Basu   +2 more
doaj   +1 more source

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

Chandipura virus replication in Vero cells is inhibited by host restriction factors APOBEC3G and IFITM3

The Microbe
Chandipura virus (CHPV) is an emerging pathogen of Indian subcontinent and in some West African countries. The virus causes fever, encephalitis and death among young children and there is no vaccine or drug available till date to treat CHPV infection ...
Dibyakanti Mandal
doaj   +1 more source

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

mBio
Viruses transit from a low to high multiplicity of infection (MOI) regime in infected tissues. Type-1 interferons (IFNs) enforce a cellular state refractory to virus multiplication, while the death of infected cells eliminates viral replicative niche ...
Bhawna, Swapnava Basu, Syed Yusuf Mian, Sanchi Arora, Yashika Ratra, Kasturi Ganguly, Sachendra S. Bais, Manidipa Banerjee, Abhyudai Singh, Soumen Basak   +9 more
doaj   +1 more source

Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis [PDF]

Journal of Neurochemistry, 2015
AbstractChandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) induces neuronal death through the Fas‐mediated extrinsic apoptosis pathway. What propels this apoptosis remains unclear, although oxysterols have been reported to be key players in neurodegeneration.
Sourish, Ghosh, Sriparna, Mukherjee, Anirban, Basu   +2 more
openaire   +2 more sources

Isolation and phylogenetic characterization of arboviruses circulating among phlebotomine sandflies in parts of North Rift, Kenya

Frontiers in Virology
BackgroundUntil recently, arbovirus surveillance is mainly focused on mosquito and tick vectors, resulting in the discovery of several mosquito- and tick-borne arboviruses. However, the role of sandflies in arbovirus transmission and disease has remained
Edith Koskei, Edith Koskei, Solomon Langat, James Mutisya, Francis Mulwa, Joel Lutomiah, Hellen Koka, Samuel O. Oyola, Rebecca Waihenya, Sepha N. Mabeya, Rosemary Sang, Rosemary Sang   +11 more
doaj   +1 more source

Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses

Viruses, 2019
Vesicular stomatitis virus (VSV) represents a promising platform for developing oncolytic viruses, as well as vaccines against significant human pathogens.
Minako Ogino, Yuriy Fedorov, Drew J. Adams, Kazuma Okada, Naoto Ito, Makoto Sugiyama, Tomoaki Ogino   +6 more
doaj   +1 more source

Animal models for Chandipura virus (CHPV) research: a comprehensive review

Discover Viruses
Chandipura virus (CHPV), a neurotropic arbovirus belonging to the Rhabdoviridae family, is linked to recurring outbreaks of acute encephalitis disease in India, primarily affecting children and exhibiting significant mortality rates.
Thuruthiyil Ramachandran Divya, Srinivas Vilasagaram, Mukesh Kumar Gupta, Ravindran Kumar Pramod   +3 more
doaj   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Immunity, Inflammation and Disease
Background Chandipura virus (CHPV), a neurotropic, negative‐sense RNA virus belonging to the genus Vesiculovirus (family Rhabdoviridae), has emerged as a significant cause of acute encephalitis syndrome (AES) in India, predominantly affecting children ...
Abrar Ahmad Zargar, Reena Gupta, P. Krishnamoorthy   +2 more
doaj   +1 more source