Results 191 to 200 of about 559 (225)

Persistent but weak magnetic field at the Moon's midstage revealed by Chang'e-5 basalt. [PDF]

Sci Adv
Cai S, Qin H, Wang H, Deng C, Yang S, Xu Y, Zhang C, Tang X, Gu L, Li X, Shen Z, Zhang M, He K, Qi K, Fan Y, Dong L, Hou Y, Shi P, Liu S, Su F, Chen Y, Li Q, Li J, Mitchell RN, He H, Li C, Pan Y, Zhu R.   +27 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Moon goddess's magnetic midlife. [PDF]

Sci Adv
Weiss BP.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lunar farside volcanism 2.8 billion years ago from Chang'e-6 basalts. [PDF]

Nature
Zhang QWL, Yang MH, Li QL, Liu Y, Yue ZY, Zhou Q, Chen LY, Ma HX, Yang SH, Tang X, Zhang GL, Ren X, Li XH.   +12 more
europepmc   +1 more source

Identification of small impact craters in Chang’e-4 landing areas using a new multi-scale fusion crater detection algorithm

Fangchao Liu, Huiwen Liu, Zhang Li, Chen Jian, Guo DiJun, Bo Li, Liu Changqing, 凌宗成 LING Zong-cheng, Lu Ying-Bo, Yao JunSheng   +9 more
openalex   +1 more source

Thermal design and flight validation of the chang’e-4 relay satellite [PDF]

Ren Hongyan, Changpeng Yang, Tengfei Sun, Xing Huang   +3 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Space weathering on the lunar nearside and farside constrained from Si isotopes. [PDF]

Nat Commun
Zhang HY, Yu HM, Tang HL, Lin YC, Xiao Z, Yang L, Kang JT, Shen J, Qin L, Huang F.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source