Results 121 to 130 of about 8,419,467 (214)

Two-billion-year-old volcanism on the Moon from Chang'e-5 basalts. [PDF]

Nature, 2021
Li QL, Zhou Q, Liu Y, Xiao Z, Lin Y, Li JH, Ma HX, Tang GQ, Guo S, Tang X, Yuan JY, Li J, Wu FY, Ouyang Z, Li C, Li XH.   +15 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A dry lunar mantle reservoir for young mare basalts of Chang'e-5. [PDF]

Nature, 2021
Hu S, He H, Ji J, Lin Y, Hui H, Anand M, Tartèse R, Yan Y, Hao J, Li R, Gu L, Guo Q, He H, Ouyang Z.   +13 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Redox condition changes caused by impacts: Insights from Chang’e-5 lunar glass beads

This file contains the figures, supplementary figures and tables, supplementary excel, and diffusion modeling codes used in the manuscript entitled "Redox condition changes caused by impacts: Insights from Chang’e-5 lunar glass beads" by Pang ...
Pang, R (via Mendeley Data)
core   +1 more source

New Lunar Samples Returned by Chang'e-5: Opportunities for New Discoveries and International Collaboration. [PDF]

Innovation (Camb), 2021
Yang W, Lin Y.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Distribution and Abundance of Solar Wind‐Derived Water in Chang'E‐5 Core Samples and Its Implications

Geophysical Research Letters
Knowledge regarding the abundance and distribution of solar wind (SW)‐sourced water (OH/H2O) on the Moon in the shallow subsurface remains limited. Here, we report the NanoSIMS measurements of H abundances and D/H ratios on soil grains from three deepest
Heng‐Ci Tian, Jialong Hao, Yangting Lin, Yuchen Xu, Ziliang Jin, Chi Zhang, Wei Yang, Sen Hu, Ruiying Li, Zongyu Yue, Qiuli Li, Yong Wei, Xianhua Li, Fuyuan Wu   +13 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source