Results 251 to 260 of about 34,281,837 (318)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The Vulnerability of Chinese Theaceae Species Under Future Climate Change. [PDF]

Biology (Basel)
Zhao X, Tang J, Zhu J, Yao L, Ai X, Xu H, Ma G, Jiang J, Yu H, Ke Z.   +9 more
europepmc   +1 more source

Why climate action is an opportunity multiplier for mental health. [PDF]

World Psychiatry
Lawrance EL.
europepmc   +1 more source

Event Knowledge Modulates Real-Time Mental Representations of Object State-Change. [PDF]

Cogn Sci
Lee SH, Kaiser E.
europepmc   +1 more source

Behaviour Change for Physical Activity Is Feasible and Effective in Women Living with Metastatic Breast Cancer: A Pilot Two-Arm Randomised Trial. [PDF]

Cancers (Basel)
Liu M, Kilbreath S, Yee J, Beith J, Dylke E.   +4 more
europepmc   +1 more source

Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies. [PDF]

PLoS Med
Alves F, Ayton S.
europepmc   +1 more source

Efficacy and safety of vemircopan as monotherapy in patients with paroxysmal nocturnal hemoglobinuria. [PDF]

Blood Adv
Kulasekararaj A, Browett P, Risitano AM, Patriquin CJ, Yenerel MN, Marceau D, Sahin F, Algarra JL, Ogawa M, Yu J, Cross NB, Notaro R, Lee JW, Brodsky RA.   +13 more
europepmc   +1 more source