Results 261 to 270 of about 3,117,785 (309)

Assessment of weight change patterns following Roux en Y gastric bypass, one anastomosis gastric bypass and sleeve gastrectomy using change-point analysis. [PDF]

Sci Rep
Boustani P, Sheidaei A, Mokhber S, Pazouki A.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

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The Point Is to Change It

Monthly Review, 2021
We who are engaged in the struggle for change might ask: "Through what lens of refraction is the evidence of events recalled and related?" If we are to resist the genocidal use of military force, and to oppose the environmental depredation that follows in its wake, we need to see the roots and laws of motion of colonialism and ...
  +4 more sources

Tests for a change-point

Biometrika, 1987
The problem is that of testing for a change of the mean in a sequence of independent normal random variables with the same variance. Well-known tests such as likelihood ratio tests, tests based upon cusums of recursive residuals, Pettitt's test and the Chernoff-Zacks' statistic are investigated again through their approximate power.
James, Barry, James, Kang Ling, Siegmund, David   +2 more
openaire   +2 more sources

Ensembles of change-point methods to estimate the change point in residual sequences

Soft Computing, 2013
Change-point methods (CPMs) are statistical tests design to assess whether a given sequence comes from an unique, stationary, data-generating process. CPMs eventually estimate the change-point location, i.e., the point where the data-generating process shifted. While there exists a large literature concerning CPMs meant for sequences of independent and
ALIPPI, CESARE, BORACCHI, GIACOMO, ROVERI, MANUEL   +2 more
openaire   +1 more source

The point is to change it

Worldviews, 2018
Like most organisations of the far left in Britain in the years after 1968, the RCP was small in size and marginal in influence. Starting out with only a few dozen supporters in the mid-1970s, membership peaked at around 200 before its demise in the mid-1990s.
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The Point is to Change it

2010
Introduction: The Point Is To Change It: Noel Castree, Paul Chatterton, Nik Heynen, Wendy Larner and Melissa W. Wright 1 Now and Then: Michael J. Watts 2 The Idea of Socialism: From 1968 to the Present-day Crisis: Hugo Radice 3 The Revolutionary Imperative: Neil Smith 4 To Make Live or Let Die?
Castree, N, Chatterton, P, Heynen, N, Larner, W, Wright, M   +4 more
openaire   +2 more sources