Results 261 to 270 of about 961,218 (296)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

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Parallelization of Change Point Detection

The Journal of Physical Chemistry A, 2017
The change point detection method ( Watkins , L. P. ; Yang , H. J. Phys. Chem. B 2005 , 109 , 617 ) allows the objective identification and isolation of abrupt changes along a data series. Because this method is grounded in statistical tests, it is particularly powerful for probing complex and noisy signals without artificially imposing a kinetics ...
Nancy Song, Haw Yang
openaire   +2 more sources

Multiscale Change Point Detection

Theory of Probability & Its Applications, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Suvorikova, A., Spokoiny, V.
openaire   +2 more sources

Change Point Detection

2021
In situ TEM and other dynamic imaging instruments alter the landscape of materials science and engineering. The unique and unprecedented ability to observe the transformation of nanoscale objects as it occurs is unparalleled in comparison to other material characterization methods, and is of tremendous value to material scientists and engineers who ...
Chiwoo Park, Yu Ding
openaire   +1 more source

Greedy Kernel Change-Point Detection

IEEE Transactions on Signal Processing, 2019
We consider the problem of detecting abrupt changes in the underlying stochastic structure of multivariate signals. A novel non-parametric and model-free off-line change-point detection method based on a kernel mapping is presented. This approach is sequential and alternates between two steps: a greedy detection to estimate a new breakpoint and a ...
Charles Truong, Laurent Oudre, Nicolas Vayatis   +2 more
openaire   +1 more source