Results 101 to 110 of about 15,871,401 (350)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Democratic Consent Under False Pretences

Political Philosophy
Democratically, the permission of any candidate or party to occupy office is based on consent conferred upon them by voters in the previous election. This article examines why and how political misinformation affects that collective electoral consent ...
Ana Tanasoca
doaj   +2 more sources

Usefulness of INTELLiVENT-ASV for postoperative ventilator-associated pneumonia: a case report

JA Clinical Reports, 2019
Background INTELLiVENT®-ASV (iASV) is a respiration mode on the Hamilton G5. The ventilator uses a closed-loop mechanism that automatically adjusts settings related to oxygenation and ventilation.
Takayuki Taira, Tatsuya Fuchigami, Misuzu Hayashi, Kouta Kamizato, Kouji Teruya, Manabu Kakinohana   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Construction industry forecasting system dynamic model [PDF]

In a paper construction branch forecasting model which allows to estimate the industry development problems is shown. Difference from anthers models, in given paper the main attention is turned to the building of the living area.
Skribans, Valerijs
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

From Expected Utility Theory to Prospect Theory : Tracking Down the Experimental Path After Forty Years

Operations Research and Decisions, 2020
The expected utility theory axioms have been studied experimentally. Three of the experiments are a repetition of an earlier test in slightly changed circumstances, while the other two are original.
Sławomir Kalinowski
doaj  

Persistent andragogical patterns across the generations: From university tutorial classes to postgraduate online education [PDF]

, 2017
The concept of design patterns in education raises the question of whether their validity can persist over a period of time or whether social and technological change means that yesterday’s virtues are today’s irrelevancies.
Kingsley , Paul
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

An Internal Clustering Validation Index for Boolean Data

Cybernetics and Information Technologies, 2016
Internal clustering validation is recognized as one of the vital issues essential to clustering applications, especially when external information is not available. Existing measures have their limitations in different application circumstances.
Fu Liwei, Wu Sen
doaj   +1 more source