Results 111 to 120 of about 22,201,636 (348)
Calenda, 2003 Durant cette rencontre on s’interrogera sur les transformations des sociétés plongées dans l’expérience de la guerre.
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Disparités et changement social
Calenda, 2013 Les doctorants du CEPED organisent le 4 juin 2013 à l'Université Paris Descartes, un colloque sur « disparités et changement social ». Ce colloque s'adresse aux doctorants en sciences humaines et sociales (sociologie, anthropologie, démographie, sociolinguistique, histoire, économie, géographie).
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Changement technologique et changement social, essais de définitions
Journal de la Recherche Scientifique de l’Université de Lomé, 2007 (Journal de la Recherche Scientifique de l'Université de Lomé: 2001 5(1): 29-36)
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The impact of global changes on agriculture: the case of Ivorian Basin of Comoe River. [P-3330-16] [PDF]
, 2015 Since some decades, the Ivorian Comoe river Basin faced environmental and climatic changes. As one of rainfed agriculture leading forces, climate conditions display (here) a major role in agriculture transformations.
Dabissi, N. +6 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Droit, contexte et changement social
Revue interdisciplinaire d'études juridiques, 2013 Pourquoi certaines transformations sociales se repercutent-elles dans le droit et d’autres pas ? Qu’est-ce qui, a l’inverse, amene l’ordre juridique a tenter de provoquer des changements sociaux ? Et pourquoi le droit parvient-il, dans certains cas, a transformer les pratiques sociales et dans d’autres, y echoue ?
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