Results 141 to 150 of about 22,201,636 (348)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Policy Change in the Canadian Welfare State: Comparing the Canada Pension Plan and Unemployment Insurance [PDF]
Focusing on Canada, this paper explores the politics of social policy retrenchment and restructuring in two policy areas: old-age pensions, especially the Canada Pension Plan (CPP), and Employment Insurance (EI) [formerly Unemployment Insurance (UI ...
Daniel Béland, John Myles
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L'anthropologie du changement social et du développement comme ambition théorique ?
, 1991 J. O. D. Sardan
semanticscholar +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Vulnérabilités sociales et changement d'échelle
Espace populations sociétés, 2017 If social vulnerability characterizes and impacts life at the individual scale, social structures enables its consequences to mitigate or amplify it, acting as a catalyst. How can a geographer be useful at this stage? A first answer could be obvious: providing a geography of vulnerable population, a description of their location, underlining the ...
Marion Borderon, Sébastien Oliveau
openaire +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
One more step towards participatory modeling. Involving local stakeholders in designing scientific models for participative foresight studies [PDF]
, 2011 This paper focuses on the collective design and immediate execution of an agent-based model (ABM) by dynamically interpreting activity diagrams of agent behaviors.
Bartaburu, Danilo +7 more
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