Results 51 to 60 of about 11,809,525 (251)
Sciences, Eaux & Territoires, 2014 La baisse de population et de services dans les zones rurales préoccupe les décideurs locaux. Face aux changements de politiques et de marchés, ces décideurs ne disposent pas d'outils de diagnostics pour anticiper les effets conjoints de tels changements
P. VEYSSET, H. RAPEY
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Travailler sur le travail. Histoire de vie et choix théorique.
, 2020 International audienceCe livre donne à lire, dans un mouvement spéculaire, l'analyse du travail des chercheurs... spécialistes du travail. Il nous renseigne également sur la construction sociale des objets, des débats théoriques et méthodologiques dans ...
Dujarier, Marie-Anne
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Transformation des référentiels de légitimité et recomposition de la cohésion sociale à Lumumbaville: entre autorité coutumière et institutions étatiques [PDF]
Mouvements et Enjeux SociauxCette étude analyse les transformations des référentiels de légitimité dans la régulation des conflits à Lumumbaville, une nouvelle entité urbaine de la République démocratique du Congo, caractérisée par une recomposition progressive de ses structures ...
Pierre Camile OKITUNDU OKONDA
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Occupational Therapists as Social Change Agents: Exploring Factors that Influence Their Actions. [PDF]
Can J Occup Ther, 2021 Picotin J +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source