Results 121 to 130 of about 520,872 (298)
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
Nytt miljonprogram unik chans att lösa flera frågor
, 2016 Dolt värde av enorma mått. Ett nytt miljonprogram kan förskräcka, men kan vara just vad Sverige behöver. Men vi ska inte upprepa misstagen från förra gången.
Lars, Marcus, +5 more
core +1 more source
Animal stroke models and outcome evaluation: A review
Animal Models and Experimental Medicine, EarlyView.Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba +2 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon +5 more
wiley +1 more source
TADF‐Active Tetrazole Luminophores for Visible‐Light Functionalization of Nanoparticles and Surfaces
Angewandte Chemie, EarlyView.A series of tetrazoles are reported that undergo 1,3‐dipolar cycloadditions with alkene and alkyne substrates, generating (dihydro)pyrazole products that exhibit thermally activated delayed fluorescence (TADF). The “photo‐click” reactivity of these tetrazoles is leveraged to functionalize nanoparticles and surfaces with TADF‐active chromophores ...
Ryoga Hojo +11 more
wiley +2 more sources
Managing coupled human and natural systems (CHANS) : the case of water [Elektronisk resurs]
, 2022 Many sustainability challenges of the 21st century are the result of poor management of coupled human and natural systems (CHANS). Limited understanding of the mechanisms that give rise to complex dynamics in CHANS has contributed to overexploitation and
Nicolaidis, Andreas, +1 more
core
Advanced NanoBiomed Research, EarlyView.Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab +8 more
wiley +1 more source
American Journal of Respiratory and Critical Care Medicine, 2023 Christopher S. Ambrose +12 more
openaire +6 more sources
From “Chan Practitioners” to “Chan School”: The Establishment of the Chan School in China
Journal of Indian and Buddhist Studies (Indogaku Bukkyogaku Kenkyu), 2023 openaire +1 more source
Die tRNA‐Modifikation Geranyl‐2‐thiouridin ermöglicht eine RNA‐Lipid Assoziation
Angewandte Chemie, EarlyView.Wir berichten über die Herstellung mono‐ bis tri‐geranylierter RNA und über die Assoziation hydrophober RNA mit Membranen für einen künftigen effizienten Einbau von RNA in Liposomen. ZUSAMMENFASSUNG Die Verpackung von RNA in Lipid‐Nanopartikeln zum Schutz und Transport war für die Entwicklung von mRNA‐Impfstoffen und Medikamenten entscheidend.
Johannes Singer +3 more
wiley +1 more source