Results 41 to 50 of about 485 (235)

A High‐Performance Coupled Human And Natural Systems (CHANS) Model for Flood Risk Assessment and Reduction

Water Resources Research
In recent years, flood risk in urban areas has been rapidly increasing due to unsustainable urban development, changes of hydrological processes and frequent occurrence of extreme weather events.
Haoyang Qin, Qiuhua Liang, Huili Chen, Varuna DeSilva   +3 more
doaj   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

An overview of FRIDA v2.1: a feedback-based, fully coupled, global integrated assessment model of climate and humans [PDF]

Geoscientific Model Development
The current crop of models assessed by the Intergovernmental Panel on Climate Change (IPCC) to produce their assessment reports lack endogenous process-based representations of climate-driven changes to human activities, especially beyond the purely ...
W. Schoenberg, W. Schoenberg, B. Blanz, J. K. Rajah, B. Callegari, C. Wells, J. Breier, M. B. Grimeland, A. N. Lindqvist, A. N. Lindqvist, L. Ramme, C. Smith, C. Smith, C. Li, S. Mashhadi, A. Muralidhar, C. Mauritzen   +16 more
doaj   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Heparprotective effect of Bergenia crassifolia extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid

Бюллетень сибирской медицины, 2007
The object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy.
D. V. Shutov
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Chan Chan: Andean Desert City. [PDF]

Man, 1983
John V. Murra, Michael E. Moseley, Kent C. Day   +2 more
openaire   +2 more sources

Coupled human and natural systems approach to wildlife research and conservation

Ecology and Society, 2014
Conserving wildlife while simultaneously meeting the resource needs of a growing human population is a major sustainability challenge. As such, using combined social and environmental perspectives to understand how people and wildlife are interlinked ...
Neil H. Carter, Andrés Viña, Vanessa Hull, William J. McConnell, William Axinn, Dirgha Ghimire, Jianguo Liu   +6 more
doaj   +1 more source