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Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source

Optical Charge Trap Memory Based on Graphene/ZnO Heterostructures for Long‐Term Retention and Adaptive Learning

Advanced Electronic Materials, EarlyView.
A biocompatible graphene/ZnO optical charge trap memory (CTM) is reported with over 54 h retention, enabled by interfacial photodoping. Using transient absorption spectroscopy and electrical analysis, charge transfer quenching is elucidated and reveal that a large energy barrier at the interface is responsible for long‐term memory retention.
Seungmin Shin +10 more
wiley +1 more source

Inta Ezergailis : 9/11/1932 - 1/1/2005 [PDF]

, 2010
Words spoken at the Memorial Service on March 13, 2005, Sage Chapel, Cornell ...
Deinert, Herbert
core

La mujer granadina como mecenas de espacios funerarios durante el Antiguo Régimen / The Women of Granada as Patrons of Funeral Spaces during the Ancien Régime

Asparkía, 2010
RESUMEN: En la Granada moderna, en un momento histórico en que la mujer estaba muy limitada legal y socialmente, se pueden encontrar casos excepcionales en los que estas se convirtieron en promotoras de importantes espacios concebidos como sepultura de ...
María José Collado Ruiz
doaj

Religious life of a provincial town in the 18th – early 20th centuries (based on the materials of the Olonets diocese)

Studia Humanitatis, 2023
The article discusses the main patterns of religious life of the Olonets diocese towns over a long and significant period of Church history. It was revealed that due to the difference in historical destinies, the towns of the Olonets diocese had ...
Pulkin Maxim Viktorovich
doaj

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li +25 more
wiley +1 more source

William Burges and Jesus Christ: Visual Theology, Consolation, and Resurrection

19
William Burges’s commissions included reliquaries and private chapels for Lord Bute and Lord Ripon, both prominent Catholic convert patrons in the 1860s and 1870s. This article explores Burges’s focus on the image of Christ and its many meanings, arguing
Ayla Lepine
doaj +2 more sources

Genome‐Wide Association Study of Symptom Change Following Cognitive Behavioral Therapy for Common Mental Disorders

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Cognitive behavioral therapy (CBT) is a well‐established, evidence‐based treatment for common mental disorders such as depression, anxiety disorders, and obsessive‐compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement.
Julia Bäckman +41 more
wiley +1 more source

Are There Causal Associations Between Obsessive‐Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi‐Directional Mendelian Randomization Study

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In epidemiological studies, obsessive‐compulsive disorder (OCD) is robustly associated with increased risk of cardiometabolic disorders, including cardiovascular diseases, type 2 diabetes, and obesity. However, the mechanisms behind these associations are unclear. We conducted genetic correlation analyses to explore shared genetic etiology and
Robyn E. Wootton +217 more
wiley +1 more source

Premières réflexions théoriques sur l’architecture des hôtels-Dieu au XVIIIe siècle

In Situ, 2017
From 1722 to 1728, Antoine Desgodets, professor at the royal architectural academy, gave a course on the commodity of different building types. He offers a model for a Hôtel-Dieu and gives one of the first theoretical syntheses for this sort of building.
Hélène Rousteau-Chambon
doaj +1 more source

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