Interface mutation in heptameric co-chaperonin protein 10 destabilizes subunits but not interfaces
Archives of Biochemistry and Biophysics, 2005We here report on a human mitochondrial co-chaperonin protein 10 (cpn10) variant in which the conserved interface residue leucine-96 is replaced with glycine (Leu96Gly cpn10). According to analytical ultracentrifugation, the mutation does not perturb the ability to assemble into a heptamer and electron microscopy reveals that Leu96Gly cpn10 is ring ...
Christopher, Brown +2 more
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Folding and assembly pathways of co-chaperonin proteins 10: Origin of bacterial thermostability
Archives of Biochemistry and Biophysics, 2006To compare folding/assembly processes of heptameric co-chaperonin proteins 10 (cpn10) from different species and search for the origin of thermostability in hyper-thermostable Aquifex aeolicus cpn10 (Aacpn10), we have studied two bacterial variants-Aacpn10 and Escherichia coli cpn10 (GroES)-and compared the results to data on Homo sapiens cpn10 ...
Kathryn, Luke +1 more
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Chaperonin 10, a Pro- and Anti-inflammatory Host Modulator
2013Chaperonin(Cpn) 10 is a 10 kDa heat shock protein/cell stress protein which has an extraordinary range of biologically important activities. Human Cpn10 is found in the sera of pregnant women and pregnant animals. In this context it is known as Early Pregnancy Factor.
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Identification of early pregnancy factor as chaperonin 10: implications for understanding its role
Reviews of Reproduction, 1996Early pregnancy factor (EPF) is a secreted substance with growth regulatory and immunomodulatory properties. It is required for successful establishment of pregnancy and for proliferation of both normal and neoplastic cells, in vivo and in vitro. The rosette inhibition test was used as a bioassay, and the appearance of EPF in serum in the very early ...
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XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.
Current opinion in investigational drugs (London, England : 2000), 2008CBio Ltd, under license from the University of Queensland, is developing a recombinant form of chaperonin 10, known as XToll, for the potential anti-inflammatory treatment of rheumatoid arthritis, psoriasis and multiple sclerosis. All three indications have been evaluated in phase IIa clinical trials.
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Chaperonin 10 for rheumatoid arthritis – Authors' reply
The Lancet, 2006D Vanags +3 more
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[17] Purification of yeast mitochondrial chaperonin 60 and co-chaperonin 10
1998Yves Dubaquié +2 more
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GroEL Ring Separation and Exchange in the Chaperonin Reaction
Cell, 2018Andreas Bracher +2 more
exaly
Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC
Cell, 2018David Balchin +2 more
exaly
Purification of yeast mitochondrial chaperonin 60 and co-chaperonin 10.
Methods in enzymology, 1998Y, Dubaquié, G, Schatz, S, Rospert
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