Results 141 to 150 of about 18,980 (171)

Chaperonin‐containing tailless complex polypeptide 1 subunit 6A correlates with increased World Health Organization grade, less isocitrate dehydrogenase mutation, and deteriorative survival of astrocytoma patients

Journal of Clinical Laboratory Analysis, 2021
Chaperonin‐containing tailless complex polypeptide 1 subunit 6A (CCT6A) is reported to be an efficient prognostic biomarker in various cancers, but it is rarely reported in astrocytoma.
Peng Fu, Hongyang Zhao, Fangcheng Zhang   +2 more
exaly   +2 more sources

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Chaperonin-containing tailless complex polypeptide 1 subunit 6A links with aggravating tumor features and disease-free survival in surgical gastric cancer patients: A long-term follow-up study

Clinics and Research in Hepatology and Gastroenterology, 2022
BACKGROUND Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) promotes several gastrointestinal-cancer malignant behaviors, while its clinical value in surgical gastric cancer is not clear. Hence, we aimed to investigate this issue.
Zhenfeng Wang, Dapeng Wang
exaly   +2 more sources

Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.

Toxicology and Applied Pharmacology, 2022
The implication of chaperonin containing T-complex protein-1 subunit 3 (CCT3) in carcinogenesis has been observed in a diverse malignancies. However, the relevance of CCT3 in non-small cell lung cancer (NSCLC) has not been well addressed.
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu, Wei Li   +5 more
semanticscholar   +1 more source

Cdna Cloning and Expression Analysis of Chaperonin Containing T-Complex Polypeptide 1-Alpha in the Pearl Oyster Pinctada maxima Exposed to Cold Stress

Journal of Shellfish Research, 2022
The complete cDNA sequence of chaperonin-containing T-complex polypeptide 1-alpha (CCT-alpha) gene of the pearl oyster Pinctada maxima was determined using rapid amplification of cDNA ends technique and characterized with bioinformatic analysis.
Xiaocheng Tang, Aitao Mao, Yu Ding, Zhigang Liu, Huazhong Liu   +4 more
semanticscholar   +1 more source

Functional characterization of chaperonin containing T-complex polypeptide-1 and its conserved and novel substrates in Arabidopsis

Journal of Experimental Botany, 2019
In plants, chaperonin containing T-complex polypeptide-1 is a chaperonin protein complex of eight subunits that participates in the folding of tubulins and the catalytic subunit of protein phosphatase 4.
Hee-Kyung Ahn, Ilyeong ‍Choi, Sumin Kim   +2 more
exaly   +2 more sources

Genetic expansion of chaperonin‐containing TCP‐1 (CCT/TRiC) complex subunits yields testis‐specific isoforms required for spermatogenesis in planarian flatworms

Molecular Reproduction and Development, 2017
Chaperonin‐containing Tail‐less complex polypeptide 1 (CCT) is a highly conserved, hetero‐oligomeric complex that ensures proper folding of actin, tubulin, and regulators of mitosis.
Labib Rouhana
exaly   +2 more sources

Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation

Cancer Immunology and Immunotherapy
Chaperonin containing TCP1 subunit 5 (CCT5), a vital component of the molecular chaperonin complex, has been implicated in tumorigenesis, cancer stemness maintenance, and therapeutic resistance.
Jiajun Li, Nuo Xu, Leyin Hu, Jiayue Xu, Yifan Huang, Deqi Wang, Feng Chen, Yi Wang, Jiani Jiang, Yanggang Hong, Huajun Ye   +10 more
semanticscholar   +1 more source

Chaperonin-containing tailless complex polypeptide 1 subunit 6A negatively regulates autophagy and protects colorectal cancer cells from cisplatin-induced cytotoxicity

World Journal of Gastroenterology
BACKGROUND As a member of the chaperonin-containing tailless complex polypeptide 1 (TCP1) complex, which plays a pivotal role in ensuring the accurate folding of numerous proteins, chaperonin-containing TCP1 subunit 6A (CCT6A) participates in various ...
Jian-Xing Ma, Xiao-Jun Li, Yali Li, Mingchan Liu, Ruihang Du, Yi Cheng, Liangjie Li, Zhiying Ai, Jian Jiang, Siyuan Yan   +9 more
semanticscholar   +1 more source

Chaperonin‐containing TCP1 subunit 6A inhibition via TRIM21‐mediated K48‐linked ubiquitination suppresses triple‐negative breast cancer progression through the AKT signalling pathway

Clinical and Translational Medicine
Background Triple‐negative breast cancer (TNBC) is distinguished by a significant likelihood of distant recurrence and an unfavourable prognosis. However, the underlying molecules and mechanisms have not been fully elucidated. Methods We investigated the
Mengdi Yang, Jianing Cao, Tiantian Liu, Bin Li, Jinyan Wang, S. Pan, Duancheng Guo, Z. Tao, Xichun Hu   +8 more
semanticscholar   +1 more source

Clinical and prognostic value of chaperonin containing T-complex 1 subunit 3 in hepatocellular carcinoma: A Study based on microarray and RNA-sequencing with 4272 cases.

Pathology, Research and Practice, 2019
Liver cancer is one of the few tumors with a steadily increasing morbidity and mortality; hepatocellular carcinoma (HCC) is the most common type of primary liver cancer.
Jia-yin Hou, Hua-Yu Wu, R. He, P. Lin, Y. Dang, Gang Chen   +5 more
semanticscholar   +1 more source