Results 201 to 210 of about 4,920,840 (345)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Integration of affective cues in context-rich and dynamic scenes varies across individuals. [PDF]

Nat Commun
Ortega J, Murai Y, Whitney D.
europepmc   +1 more source

Studies on the characters of seeds and their after-effects on the next generation of rice plahts cultivated at different localities.

, 1956
T. Matsuo, Yuzo FUTSUHARA, Ken-ich OSONE
openalex   +2 more sources

The mechanism of the characters of inorganic carbon acquisition to temperature in two Ulva species [PDF]

, 2013
徐军田 XU Juntian, 王学文 WANG Xuewen, 钟志海 ZHONG Zhihai, 姚东瑞 YAO Dongrui   +3 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach. [PDF]

Front Aging Neurosci
Mekulu K, Aqlan F, Yang H.
europepmc   +1 more source

The role of folklore in shaping the Leukonese characters: An anthropolinguistic study

Tasnim Lubis, T. Thyrhaya Zein, Amalia Amalia   +2 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comparative anatomy of the thoracic muscles of bees (Hymenoptera: Apoidea). [PDF]

PeerJ
Meira OM, Almeida EAB.
europepmc   +1 more source

Nutritional Characters [PDF]

Journal of General Microbiology, 1955
openaire   +2 more sources