Results 231 to 240 of about 1,651,705 (291)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A large-scale benchmark dataset for Urdu script optical character recognition with systematic augmentation. [PDF]

Data Brief
Yasir F, Kazmi M, Qazi SA.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

First-Principles Study of Sr_2-<i>x</i> La _<i>x</i> FeO₄ and Comparison with Sr₂FeO_4‑δ: The Nature of the Positively Charged Defect Determines the Character of the Electronic Structure. [PDF]

J Phys Chem C Nanomater Interfaces
Mastrikov YA, Gryaznov D, Chesnokov A, Zvejnieks G, Sokolov M, Kuklja MM, Merkle R, Kotomin E.   +7 more
europepmc   +1 more source

Phylogenetic Inference from Atomized 3D Morphometric Data: A Case Study using Kangaroos. [PDF]

Syst Biol
Celik MA, Fruciano C, Butler K, Weisbecker V, Phillips MJ.   +4 more
europepmc   +1 more source

Large-Scale Quantum Computing Emulation for Accurate Triplet States of Ir(III) and Pt(II) Phosphorescent Emitters. [PDF]

J Am Chem Soc
Genin SN, Kwon O, Hosseini Jenab SM, Lim SJ, Kim T, Kim TG, Gherib R, Harper AF, Ryabinkin IG, Helander MG.   +9 more
europepmc   +1 more source

Linguistic markers of deception in Arabic news headlines: A cross-corpus study of stylistic and numeric features. [PDF]

PLoS One
Albtoush ES, Gan KH, Alrababah SAA.
europepmc   +1 more source

Between experience and measurement: masters athletes' perceptions of the 5Cs and a proposed measure. [PDF]

Front Sports Act Living
da Silva MPP, Peixoto EM.
europepmc   +1 more source

Vibrational circular dichroism enhancement in conformationally flexible transition metal complexes.

Phys Chem Chem Phys
Sapova M, de Boer M, Buma WJ, Visscher L.   +3 more
europepmc   +1 more source