Results 41 to 50 of about 4,505,741 (323)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

What can we learn from one-to-one trials in Instructional design? A case from module development

Research and Development in Education
The one-to-one trial phase within the instructional design development model has frequently been neglected in prior research. This stage should provide much in-depth insight considering its nature, which is in-depth face-to-face data collection between ...
Muhsinah Annisa, Dasim Budimansyah, Mupid Hidayat, Atiek Winarti, Fadhlan Muchlas Abrori   +4 more
doaj   +1 more source

Water Conservation Through Local Wisdom As A Manifestation Of Social Justice And Ecological Justice [PDF]

BIO Web of Conferences
In all its manifestations, the ecological crisis include water crisis, threatens our world's ecosystem. The primary cause of the crisis is human attitudes and behaviours that objectify nature.
Hermanto Candra Priskardus, Hamim Miftahul, Maulana Khabir Gedong   +2 more
doaj   +1 more source

An Explorative Study of Virtues in Ethical Consumption from a Confucian Perspective in an Urban-Rural-Fringe in China [PDF]

Business Ethics and Leadership, 2020
The concept of ethical consumption has garnered considerable attention in recent years. Yet, it remains somewhat ‘mystical’ in the existing Western literature.
Dr Yan Huo, Kristján Kristjánsson
doaj   +1 more source

Simulating Reionization: Character and Observability [PDF]

, 2007
In recent years there has been considerable progress in our understanding of the nature and properties of the reionization process. In particular, the numerical simulations of this epoch have made a qualitative leap forward, reaching sufficiently large ...
Bond, J. Richard, Iliev, Ilian T., McDonald, Patrick, Mellema, Garrelt, Pen, Ue-Li, Shapiro, Paul R.   +5 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Participation Mystique: A Theological Perspective in Achieving the Sustainable Development Goal [PDF]

Pharos Journal of Theology
The phenomenon of dehumanization and destruction of the universe is a major crisis that challenges all aspects of life, especially the moral and ethical aspect of today's global society.
Faustinus Sirken, S.S, M.A
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

A Meaningful Synergy: The Integration of Character Strengths and the Three Types of Meaning in Life

Social Sciences, 2023
Two areas that have scientifically erupted in the last two decades are the sciences of meaning and of character strengths, yet the integration of these areas has been minimal.
Pninit Russo-Netzer, Ricardo Tarrasch, Ryan M. Niemiec   +2 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source