Results 111 to 120 of about 2,777,537 (306)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Does the Winner Truly Take It All?

GiLE Journal of Skills Development
Competition is an intrinsic aspect of human behaviour, evolving from fundamental survival mechanisms to complex socio-cultural phenomena such as status acquisition, achievement recognition, and recreational engagement.
Norbert Griszbacher, Kitti Griszbacher
doaj   +1 more source

Foundations of Character - Developing Character and Values in the Early Years [PDF]

, 2010
Foundations of Character takes a deep and insightful look into character and values development during the 'early years' phase of education. It is commonly assumed that the influences on the early years of a child'slife are determinative for the ...
Arthur, James, Lin, Hsing-Chiung, Powell, Sacha   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing leadership character based on Pancasila in village government

Jurnal Kependidikan: Penelitian Inovasi Pembelajaran
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Sadono Sriharjo, Dasim Budimansyah, Yadi Ruyadi, Encep Syarief Nurdin   +3 more
doaj   +1 more source

Graduates of Character - Values and Character: Higher Education and Graduate Employment [PDF]

, 2009
Graduates of Character is the product of an empirical enquiry into the values, virtues, dispositions and attitudes of a sample of students and employees who volunteered to be involved.
Arthur, James, Godfrey, Ray, Gray, Ben, Newton, Nigel, Wilson, Kenneth   +4 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Integrated Islamic Classroom Management and its Impact on Improving the Quality of Education in Islamic Schools

Medina-Te
The research investigates the impact of integrated Islamic classroom management on improving the quality of education in Islamic schools. The primary purpose of this study is to explore how a combination of academic discipline and Islamic values in ...
Heni Feviasari, Melly Nuryani, Ikah Rohilah, Ade Budiansyah   +3 more
doaj   +1 more source