Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
The Lessons of Anapra: International Service Learning And Character Education [PDF]
, 2006 Glenda R. Balas
openalex +1 more source
Moral Turbulence and the Infusion of Multimodal Character Education Strategies in American Elementary Schools [PDF]
, 2013 Pockets of American society are marked by increase in violent crime with concurrent decline in moral character. This phenomenon is infiltrating the nation’s school system as evidenced by growing numbers of aggressive incidents in the classroom.
Cobb, M.A., Kristi L. +1 more
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Like Produces Like: John Heyl Vincent and His 19th Century Theory of Character Education [PDF]
, 2007 Catherine Ganiere +2 more
openalex +1 more source
The Development of Charater Education Model to Improve Students’ Academic Independence in Islamic Boarding School in Sinjai District, Indonesia. [PDF]
, 2016 Abstrak The Objektive of this research and development is to crate a description of the operational model of character education amnd to determine the effectiveness of a character education model in ebhancing students’ academic independence.
Bachri Thalib, Syamsul +1 more
core
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Teacher’s Education for Character Education
Proceedings of the 2nd International Conference on Social Science and Character Educations (ICoSSCE 2019), 2020 Mutiarawati Fajariah, Djoko Suryo
openaire +2 more sources
IMPLEMENTASI PENDIDIKAN KARAKTER PELAJAR PANCASILA ELEMEN BERIMAN DAN BERTAQWA KEPADA TUHAN YME DI SDN KASREMAN TULUNGAGUNG [PDF]
Yustiana, Fika. 2024. Implementation of character education for Pancasila students, elements of faith and devotion to God Almighty at SDN Kasreman Tulungagung, FKIP, University of Muhammadiyah Malang, Supervisor, (I) Bahrul Ulum., M.Pd, (II) Maharani ...
Yustiana, Fika
core