Results 131 to 140 of about 600,704 (244)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The relationship between the Ewald sphere and exit wave explored using focal series electron micrographs. [PDF]

IUCrJ
Heymann JB.
europepmc   +1 more source

Hydrological, Physical, and Chemical Functions and Connectivity of Non‐Floodplain Wetlands to Downstream Waters: A Review

Journal of the American Water Resources Association, 2018
C. Lane, S. Leibowitz, B. Autrey, S. LeDuc, L. Alexander   +4 more
semanticscholar   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Fault Diagnosis Method for Reciprocating Compressors Based on Spatio-Temporal Feature Fusion. [PDF]

Sensors (Basel)
Xu H, Ji X, Qin X, An W, Zhang F, Duan L, Wang J.   +6 more
europepmc   +1 more source

Factorisation of characteristic functions on noncommutative groups

, 1982
A. Wulfsohn
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Resurgence and Riemann-Hilbert Problems for Elliptic Calabi-Yau Threefolds. [PDF]

Commun Math Phys
Bridgeland T, Tulli I.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Brain-Oct-Pvt: A Physics-Guided Transformer with Radial Prior and Deformable Alignment for Neurovascular Segmentation. [PDF]

Bioengineering (Basel)
Lan Q, Huang J, Huang C, Song S, Shi Y, Zhao Z, Wu W, Chen H, Liu N.   +8 more
europepmc   +1 more source