Results 41 to 50 of about 600,704 (244)

Objective functions used as performance metrics for hydrological models: state-of-the-art and critical analysis

, 2020
Hydrological models (HMs) can be applied for different purposes, and a key step is model calibration using objective functions (OF) to quantify the agreement between observed and calculated discharges.
P. Ferreira, A. R. Paz, J. Bravo
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Simplified Game for Resolution of Singularities [PDF]

, 2014
We will describe a combinatorial game that models the problem of resolution of singularities of algebraic varieties over a field of characteristic zero.
Schicho, Josef
core  

Gabor Frames on Local Fields of Positive Characteristic

, 2016
Gabor frames have gained considerable popularity during the past decade, primarily due to their substantiated applications in diverse and widespread fields of engineering and science.
Shah, Firdous A.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Bounds for Calder\'on-Zygmund operators with matrix $A_2$ weights

, 2017
It is well-known that dyadic martingale transforms are a good model for Calder\'on-Zygmund singular integral operators. In this paper we extend some results on weighted norm inequalities to vector-valued functions.
Pott, Sandra, Stoica, Andrei
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Statistics of non-linear stochastic dynamical systems under L\'evy noises by a convolution quadrature approach

, 2011
This paper describes a novel numerical approach to find the statistics of the non-stationary response of scalar non-linear systems excited by L\'evy white noises.
Cottone G Di Paola M Marino F, Dybiec B, Gikhman I I, Giulio Cottone, Grigoriu M, Lin Y K, Masud A, Metzler R, Protter Philip E, Risken H, Roberts J B, Samko S G, Sobczyk K, Wedig W V, Young D M   +14 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source