Results 41 to 50 of about 24,063,264 (224)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mellin transforms with only critical zeros: Legendre functions [PDF]
, 2015 We consider the Mellin transforms of certain Legendre functions based upon the ordinary and associated Legendre polynomials. We show that the transforms have polynomial factors whose zeros lie all on the critical line View the MathML sourceRes=1/2.
Lettington, Matthew C., Coffey, Mark W.
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Stieltjes Transforms of Symmetric Probability Distribution Functions
, 2007 In this thesis, we study the Stieltjes transforms of the probability distribution functions and compare them with the characteristic functions of the probability distribution functions simultaneously.
Huang, Jyh-shin
core
Radon-type transforms for holomorphic functions in the lie ball
, 2019 In this paper, we consider holomorphic functions on the m-dimensional Lie ball LB(0,1) which admit a square integrable extension on the Lie sphere. We then define orthogonal projections of this set onto suitable subsets of functions defined in lower ...
Sabadini I. +3 more
core +1 more source
Characteristic polynomials of complex random matrix models [PDF]
, 2002 We calculate the expectation value of an arbitrary product of characteristic polynomials of complex random matrices and their hermitian conjugates. Using the technique of orthogonal polynomials in the complex plane our result can be written in terms of
Akemann, G +3 more
core +1 more source
On the Fourier transforms of retarded Lorentz-invariant functions [PDF]
, 1981 In this article we evaluate the Fourier transforms of retarded Lorentz-invariant functions (and distributions) as limits of Laplace transforms. Our method works generally for any retarded Lorentz-invariant functions φ(t) (t ε{lunate} Rn) which is ...
Trione, S.E.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source