Results 131 to 140 of about 73,095 (305)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Development and Evaluation of a Characteristic Impedance Calculator

, 2009
This paper presents our development and evaluation of a transmission line characteristic impedance calculator that offers visualization and immediate feedback.
Drewniak, J., Koul, Amendra, Wheeler, Edward, Wheeler, Edward D., Koul, A., Song, J., Song, Jianjian, Sivarajan, Vysakh, Sivarajan, V., Drewniak, James L., Hoover, Keith E., Hoover, K., Wheeler, E.   +12 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Impedance Characteristics of Orifices

Transactions of the Society of Instrument and Control Engineers, 1987
IIMURA, Ikuro, GOTO, Norio, HATANAKA, Hiroshi   +2 more
openaire   +2 more sources

Dectermine twisted-line characteristic impedance

, 2008
Made available in DSpace on 2019-09-12T16:57:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2008This approach shows how to calculate and measure the characteristic impedance of balanced twisted bifilar transmission lines using a commercial ...
Ribeiro, Jose Antonio Junstino, Pereira, Wilton Ney do Amaral, Ferreira, Antonio Alves, Jr.   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Low-characteristic-impedance superconducting tadpole resonators in the sub-gigahertz regime

Physical Review Research
We demonstrate a simple and versatile resonator design based on a short strip of a typical coplanar waveguide shorted at one end to the ground and shunted at the other end with a large parallel-plate capacitor.
Miika Rasola, Samuel Klaver, Jian Ma, Priyank Singh, Tuomas Uusnäkki, Heikki Suominen, Mikko Möttönen   +6 more
doaj   +1 more source

Ultrasonic determination of characteristic acoustic impedance of fluids

, 1987
The main objective of this study was to develop a technique for determining the characteristic acoustic impedance offluids using a transmission technique. A system analysis was made which showed that the attenuation of the medium is critically important.
Bangviwat, Athikom
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source