Results 81 to 90 of about 594,472 (279)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Novel Immune-Related Prognostic Signature for Thyroid Carcinoma
Technology in Cancer Research & Treatment, 2020 Background: Recent studies have confirmed that immune-associated genes perform a crucial function in recurrence and metastasis of thyroid carcinoma. A reliable immune-related prognostic signature for patients with thyroid cancer is needed.
Yuanbo Xue MD, Jing Li MD, Xiubo Lu MD
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
TypeA operating characteristic functions of defects sampling plans
Metrika, 1992 A type A (lot) defects sampling plan and its operating characteristic (OC) function are studied under suitable assumptions on the arrangements of the total number of defects. The distributions of the number of defects in a sample for hypergeometric and Poisson models are found and the exact OC functions are calculated.
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Prediction of cancer using customised fuzzy rough machine learning approaches
Healthcare Technology Letters, 2018 This Letter proposes a customised approach for attribute selection applied to the fuzzy rough quick reduct algorithm. The unbalanced data is balanced using synthetic minority oversampling technique.
Chinnaswamy Arunkumar +2 more
doaj +1 more source
Weyl function of a Hermitian operator and its connection with characteristic function
, 2015 Let $A$ be a densely defined symmetric operator with equal deficiency indices in a Hilbert space. We introduce the notion of a Weyl function $M(z)$ of $A$ corresponding to an ordinary boundary triplet of the operator $A^*$ and then investigate its basic properties.
Derkach, Vladimir, Malamud, Mark
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Extreme doubly stochastic operators and characteristic functions
Journal of Mathematical Analysis and Applications, 1985 Let the measure space (X,m) be the unit interval [0,1] with Lebesgue measure. A linear operator T on \(L^ 1(X,m)\) is doubly stochastic if Tf\(\geq 0\) for \(f\geq 0\), \(T1=1\), and \(\int Tf dm=\int f dm\). The doubly stochastic operators form a convex set, and the extreme points of this set are called extreme doubly stochastic operators. The authors
De Land, P.N, Shiflett, R.C
openaire +1 more source