Results 231 to 240 of about 17,601,381 (300)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

HER2 Overexpression in Invasive Breast Carcinoma in the Democratic Republic of Congo and its Association with Selected Clinicopathological Characteristics. [PDF]

Breast Cancer (Dove Med Press)
Ilunga Nday G, Ilunga Banza M, Umpungu AN, Kabamba Nzaji M, Moyambe JNT.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Investigation of Wind Field Characteristics in Mountain Valley Terrain Under the Disturbance of Bridge Structures. [PDF]

Sensors (Basel)
Wu C, Zhang J, Yang H, Liu H, Ma R.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Peer-coaching interventions for stroke survivors - what works and how: A scoping review. [PDF]

PLoS One
Chen Y, Patinadan PV, Shaik MA, Chiang HLM, Tan-Ho G, Dewanti FA, Chng MHR, Ho AHY.   +7 more
europepmc   +1 more source

Trends in Electronic Health Record Use Among Adult Day Services Centers, 2016-2022: A Cross-Sectional Panel Study. [PDF]

Health Sci Rep
Li Y, Lendon JP, Kindilien S, Caffrey C.
europepmc   +1 more source

How do staff and team characteristics relate to ward safety incidents in adult inpatient mental health settings? A protocol for a systematic integrative review. [PDF]

BMJ Open
Greenfield K, Griffin B, Kendal S, Woodnutt S, Hallett N, Johnson J, Berzins K, Bojke C, Henderson M, Lomani J, Wadey E, Baker J.   +11 more
europepmc   +1 more source