Results 191 to 200 of about 10,370,537 (363)

A complete characterization of the level spaces of R(I) and I(I) [PDF]

, 1986
R. Löwen
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Artificial Intelligence in Coronary Plaque Characterization: Clinical Implications, Evidence Gaps, and Future Directions. [PDF]

J Clin Med
Benjanuwattra J, Castillo-Rodriguez C, Abdelnabi M, Ibrahim R, Nhat Pham H, Pathangey G, Allam M, Lee K, Tamarappoo B, Jokerst C, Ayoub C, Arsanjani R.   +11 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Purification and characterization of a major glycoprotein in rat liver lysosomal membrane.

, 1990
Kenji Akasaki, Yuji Yamaguchi, Masaya Ohta, Fumito Matsuura, K. Furuno, Hiroyuki Tsuji   +5 more
openalex   +2 more sources

Identification and characterization of a spinal muscular atrophy-determining gene

Cell, 1995
S. Lefebvre, L. Bürglen, S. Reboullet, O. Clermont, P. Burlet, L. Viollet, B. Bénichou, C. Cruaud, P. Millasseau, M. Zeviani, D. Paslier, J. Frézal, D. Cohen, J. Weissenbach, A. Munnich, J. Melki   +15 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Correction: Adhikari et al. Synthesis and Characterization of Symmetrical <i>N</i>-Heterocyclic Carbene Copper(II) Complexes-An Investigation of the Influence of Pyridinyl Substituents. <i>Molecules</i> 2024, <i>29</i>, 3542. [PDF]

Molecules
Adhikari B, Raju S, Awoyemi RF, Donnadieu B, Wipf DO, Stokes SL, Emerson JP.   +6 more
europepmc   +1 more source

Characterization of victims of trauma treated in an emergency hospital

, 2011
Mariângela da Silva Nunes, Edilene Curvelo Hora, Ricardo Fakhouri, José Antônio Barreto Alves, María do Carmo de Oliveira Ribeiro, Ana Carla Ferreira Silva dos Santos   +5 more
openalex   +2 more sources

Characterization of a restriction enzyme from a strain ofNeisseria gonorrhoeawhich recognizes 5′GICCGGC3′, an isochizomer ofNael [PDF]

, 1989
Alan W. Hammond, Gary F. Gerard, James H. Campbell, Deb K. Chatterjee   +3 more
openalex   +1 more source