Results 241 to 250 of about 10,370,537 (363)
Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourcePotential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk +4 morewiley +1 more sourceComprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Cell, 2017 Adrian Ally, Miruna Balasundaram, R. Carlsen, E. Chuah, A. Clarke, Noreen Dhalla, R. Holt, Steven J. M. Jones, Darlene Lee, Yussanne Ma, M. Marra, Michael Mayo, Richard A. Moore, A. Mungall, J. Schein, Payal Sipahimalani, Angela Tam, N. Thiessen, Dorothy Cheung, Tina Wong, Denise Brooks, A. G. Robertson, R. Bowlby, K. Mungall, S. Sadeghi, Liu Xi, K. Covington, E. Shinbrot, D. Wheeler, R. Gibbs, L. Donehower, Linghua Wang, Jay Bowen, J. Gastier-Foster, M. Gerken, Carmen Helsel, K. Leraas, T. Lichtenberg, N. Ramirez, L. Wise, E. Zmuda, S. Gabriel, M. Meyerson, C. Cibulskis, Bradley A. Murray, J. Shih, R. Beroukhim, A. Cherniack, S. Schumacher, G. Saksena, C. Pedamallu, L. Chin, G. Getz, M. Noble, Hailei Zhang, David I Heiman, Juok Cho, Nils Gehlenborg, Douglas Voet, Pei Lin, S. Frazer, T. DeFreitas, S. Meier, M. Lawrence, Jaegil Kim, C. Creighton, D. Muzny, H. Doddapaneni, Jianhong Hu, Min Wang, Donna Morton, V. Korchina, Yi Han, H. Dinh, L. Lewis, Michelle Bellair, Xiuping Liu, J. Santibanez, R. Glenn, Sandy Lee, Walker Hale, J. Parker, M. Wilkerson, D. Hayes, Sheila M. Reynolds, I. Shmulevich, Wei Zhang, Yuexin Liu, L. Iype, H. Makhlouf, M. Torbenson, S. Kakar, M. Yeh, D. Jain, D. Kleiner, R. Dhanasekaran, H. El‐Serag, S. Yim, J. Weinstein, L. Mishra, Jianping Zhang, Rehan Akbani, Shiyun Ling, Z. Ju, X. Su, A. Hegde, G. Mills, Yiling Lu, J. Chen, Ju-Seog Lee, B. Sohn, Jae-Jun Shim, P. Tong, H. Aburatani, Shogo Yamamoto, K. Tatsuno, Wei Li, Zheng Xia, Nicolas Stransky, E. Seiser, F. Innocenti, Jianjiong Gao, Ritika Kundra, Hongxin Zhang, Zachary J. Heins, Angelica Ochoa, C. Sander, M. Ladanyi, R. Shen, Arshi Arora, F. Sánchez-Vega, N. Schultz, K. Kasaian, Amie Radenbaugh, K. Bissig, D. Moore, Y. Totoki, Hiromi Nakamura, T. Shibata, C. Yau, Kiley S. Graim, Josh M Stuart, D. Haussler, B. Slagle, A. Ojesina, Panagiotis Katsonis, Amanda M Koire, O. Lichtarge, Teng-Kuei Hsu, M. Ferguson, John A. Demchok, Ina Felau, Margi Sheth, R. Tarnuzzer, Zhining Wang, Liming Yang, J. Zenklusen, J. Zhang, C. Hutter, H. Sofia, R. Verhaak, Siyuan Zheng, F. Lang, Sudha Chudamani, Jia Liu, Laxmi Lolla, Ye Wu, R. Naresh, T. Pihl, Charlie Sun, Yunhu Wan, C. Benz, Amy H. Perou, L. Thorne, L. Boice, Meijuan Huang, W. Rathmell, H. Noushmehr, F. Saggioro, D. Tirapelli, C. G. C. Júnior, Ê. D. Mente, O. C. Silva, F. Trevisan, K. Kang, K. Ahn, N. Giama, C. Moser, T. Giordano, Michelle Vinco, Theodore H. Welling, D. Crain, Erin E. Curley, J. Gardner, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, R. Kelley, Joong-Won Park, V. Chandan, L. Roberts, O. Bathe, C. Hagedorn, J. Auman, D. O'Brien, J. Kocher, Corbin D. Jones, P. Mieczkowski, C. Perou, Tara J. Skelly, Donghui Tan, Umadevi Veluvolu, S. Balu, T. Bodenheimer, A. Hoyle, S. Jefferys, S. Meng, Lisle E. Mose, Yan Shi, J. Simons, Matthew G. Soloway, J. Roach, K. Hoadley, S. Baylin, Hui Shen, T. Hinoue, Moiz Bootwalla, D. V. Berg, D. Weisenberger, Phillip H. Lai, Andrea E Holbrook, Mario Berrios, P. Laird +235 moresemanticscholar +1 more sourceEffective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet +17 morewiley +1 more sourceExploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair +17 morewiley +1 more source
