Results 111 to 120 of about 1,911,436 (333)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Unveiling pressure-induced anomalous shear behavior and thermoelasticity of α-Fe2O3 hematite at high pressure

iScience
Summary: Hematite (α-Fe2O3), as an important end-member of FeO-Fe2O3 series, has garnered particular interest for its peculiar high pressure-temperature (P-T) behavior, structural stability and elasticity, and the unclear role of Fe3+ in the nature and ...
Yongtao Zou, Pei Wang, Ying Li, Haiyan Chen, Cangtao Zhou, Tetsuo Irifune   +5 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Random Measurable Sets and Covariogram Realisability Problems [PDF]

, 2015
We provide a characterization of the realisable set covariograms, bringing a rigorous yet abstract solution to the $S\_2$ problem in materials science.
Galerne, Bruno, Lachieze-Rey, Raphael
core   +2 more sources

Corrosion behavior of Al6061 alloy weldment produced by friction stir welding process

Journal of Materials Research and Technology, 2015
In this work, the corrosion behavior of welded lap joints of AA6061-T6 aluminum alloy produced by friction stir welding process has been investigated.
Farhad Gharavi, Khamirul Amin Matori, Robiah Yunus, Norinsan Kamil Othman, Firouz Fadaeifard   +4 more
doaj   +1 more source

Rare earth substitution in lattice-tuned Sr0.3Ca0.7Fe2As2 solid solutions

, 2012
The effects of aliovalent rare earth substitution on the physical properties of Sr0.3Ca0.7Fe2As2 solid solutions are explored. Electrical transport, magnetic susceptibility and structural characterization data as a function of La substitution into (Sr_1 ...
Drye, Tyler, Paglione, Johnpierre, Saha, Shanta R., Zavalij, Peter Y.   +3 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Accident Analysis in Research Reactors [PDF]

The first Research Reactor reaches its criticality on 2nd December 1942. Nowadays, more than 300 research reactors are currently in operation. Over the past fifty years, research reactors have progressed through a variety of tasks.
Adorni, Martina
core  

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source