Results 131 to 140 of about 2,686,988 (365)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Bimetal-Initiated Concerted Zn Regulation Enabling Highly Stable Aqueous Zn-Ion Batteries

Batteries
Aqueous zinc ion batteries are highly sought after for the next generation of sustainable energy storage systems. However, their development is significantly impeded by the presence of undesired zinc dendrites, which greatly reduce their cycle life.
Hong Yin, Yuliang Liu, Yifeng Zhu, Fengxiang Ye, Guangliang Xu, Mengfang Lin, Wenbin Kang   +6 more
doaj   +1 more source

Thermodynamic Geometry: Evolution, Correlation and Phase Transition

, 2010
Under the fluctuation of the electric charge and atomic mass, this paper considers the theory of the thin film depletion layer formation of an ensemble of finitely excited, non-empty $d/f$-orbital heavy materials, from the thermodynamic geometric ...
Aharony, Aman, Aman, Arcioni, Astefanesei, B.N. Tiwari, Balasubramanian, Balasubramanian, Balasubramanian, Bekenstein, Bellucci, Bellucci, Bellucci, Bellucci, Bellucci, Bellucci, Bellucci, Bellucci, Bellucci, Bloch, Bonora, Callen, Cardoso, Chandra, Chandra, Cross, Dabholkar, Dabholkar, David, de Wit, de Wit, Do Carmo, Emparan, Ferrara, Ferrara, Gaiotto, Gauntlett, Gelfand, Grant, Huang, Iyer, Jatkar, Jiang, Kaura, Krakow, Landau, Mohaupt, Nakahara, Rudin, Ruppeiner, Ruppeiner, Ruppeiner, Ruppeiner, Ruppeiner, Ruppeiner, Ruppeiner, S. Bellucci, Sahoo, Sahoo, Sarkar, Sarkar, Sen, Sen, Sen, Sen, Shen, Sze, Tisza, Venables, Wald, Wald, Weinhold, Weinhold, Widom, Yu, Zelikin   +75 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Unveiling pressure-induced anomalous shear behavior and thermoelasticity of α-Fe2O3 hematite at high pressure

iScience
Summary: Hematite (α-Fe2O3), as an important end-member of FeO-Fe2O3 series, has garnered particular interest for its peculiar high pressure-temperature (P-T) behavior, structural stability and elasticity, and the unclear role of Fe3+ in the nature and ...
Yongtao Zou, Pei Wang, Ying Li, Haiyan Chen, Cangtao Zhou, Tetsuo Irifune   +5 more
doaj   +1 more source

Corrosion behavior of Al6061 alloy weldment produced by friction stir welding process

Journal of Materials Research and Technology, 2015
In this work, the corrosion behavior of welded lap joints of AA6061-T6 aluminum alloy produced by friction stir welding process has been investigated.
Farhad Gharavi, Khamirul Amin Matori, Robiah Yunus, Norinsan Kamil Othman, Firouz Fadaeifard   +4 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Applications of synchrotron radiation to materials science: Diffraction imaging (topography) and microradiography [PDF]

Synchrotron radiation sources are now available throughout the world. The use of hard X-ray radiation from these sources for materials science is described with emphasis on diffraction imaging for material characterization.
Kuriyama, Masao
core   +1 more source

Rare earth substitution in lattice-tuned Sr0.3Ca0.7Fe2As2 solid solutions

, 2012
The effects of aliovalent rare earth substitution on the physical properties of Sr0.3Ca0.7Fe2As2 solid solutions are explored. Electrical transport, magnetic susceptibility and structural characterization data as a function of La substitution into (Sr_1 ...
Drye, Tyler, Paglione, Johnpierre, Saha, Shanta R., Zavalij, Peter Y.   +3 more
core   +1 more source