Results 31 to 40 of about 70,167 (251)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Supporting business functions influencing the formalization of charcoal business in Tanzania

Trees, Forests and People
Charcoal business, production, and sustainability are all under the control of government regulations. In Tanzania, the entire charcoal value chain employs approximately two million people. As a result, there are unreliable records for registered actors,
William Didas Marandu, Greyson Zabron Nyamoga, Romanus Ishengoma   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Understanding Livelihoods for Protected Area Management: Insights from Northern Madagascar

Conservation & Society, 2020
Protected Areas (PAs) are the most common approach to conservation globally; however, their effectiveness is unclear when neighbouring human communities are highly natural resource dependent.
Brittney I Vezina, Annick Ranaivoson, Julie H Razafimanahaka, Daudet Andriafidison, Herson Andrianirina, Khalady Ahamadi, Jeanneney Rabearivony, Charlie J Gardner   +7 more
doaj   +1 more source

Thermal Performance Analysis of Materials and Configurations for Cylindrical Sidewalls of Charcoal Kilns

Energies, 2022
Most of the charcoal in the world comes from small and medium-sized producers, using rudimentary carbonization kilns that require significant time or energy during the heating and cooling stages of the process.
Antão Rodrigo Valentim, Jhon Ramírez Behainne, Aldo Braghini Junior   +2 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Enhanced triglyceride adsorption by steam-activated bamboo charcoal based on molecular dynamics investigations

Scientific Reports
In this study, ordinary bamboo charcoal was activated at 750 °C with a steam flow rate of 6.25 L/min for 1.5 h. The effects of triglyceride adsorption by activated bamboo charcoal were investigated using an orthogonal design, and the adsorption mechanism
Hegang Zhu, Sheng Zhang, Honghui Zheng, Guifeng Wang   +3 more
doaj   +1 more source

Surface Analysis of Lithium Disilicate Ceramics After Use of Charcoal-Containing Toothpastes

Journal of Functional Biomaterials
Background: This study evaluated the effect of charcoal-containing toothpaste on the surface roughness of CAD/CAM lithium disilicate ceramic (e.max CAD) after simulated toothbrushing.
Franciele Floriani, Bayaan Jabr, Silvia Rojas-Rueda, Rene Garcia-Contreras, Carlos A. Jurado, Abdulrahman Alshabib   +5 more
doaj   +1 more source

A tethersonde measuring system for detection of O3, NO2, hydrocarbon concentrations, and meteorological parameters in the lower planetary boundary layer

Meteorologische Zeitschrift, 1993
During the Swiss POLLUMET field experiments, a tethersonde measuring system was used to determine the vertical profiles and temporal evolutions of meteorological parameters and air pollutants such as NO2, O3, and hydrocarbons (HC).
G. Baumbach, K. Baumann, A. Grauer, R. Semmler, B. Steisslinger, H. Wanner, T. Künzle, U. Neu   +7 more
doaj   +1 more source