Results 41 to 50 of about 22,116,242 (289)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Charcoal-based dentifrices and powders: analyses of product labels, Instagram engagement, and altmetrics

open access: yes, 2021
This study identified charcoal-based dentifrices and abrasive powders sold in Brazil and analyzed their label information. The products were searched in four online shopping platforms.
Laura D. Bauler (12681018)   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Chitin‐Derived Carbon‐Metal Functional Materials

open access: yesAdvanced Functional Materials, EarlyView.
Functional carbon materials are synthesized from combination of biopolymer (chitin) and iron precursors. The resultant material exhibits superior surface area and adsorptive properties compared to carbon materials synthesized directly from pure chitin.
Herry Fang   +7 more
wiley   +1 more source

Monitoring the Microwave Synthesis of d0‐Free Disordered Rocksalt Cathodes Using In Situ Infrared Pyrometry

open access: yesAngewandte Chemie, EarlyView.
Despite its promise for producing metastable materials, the mechanisms underlying solid‐state microwave synthesis remain poorly understood. By combining in situ thermography with x‐ray diffraction and solid‐state NMR, this study uncovers a surprising order–disorder–order reaction pathway during the microwave synthesis of the Li1.1Mn0.9O1.9F0.1${\rm Li ...
Erick A. Lawrence   +8 more
wiley   +2 more sources

Holocene Fire Dynamics in the Altai Mountains and Its Driving Factors

open access: yesGeophysical Research Letters
Fire activity reshapes the successions of forest and steppe ecosystems. However, the long‐term fire history and its driving factors in the Altai Mountains remain poorly documented and understood.
Yu Hu   +12 more
doaj   +1 more source

Combustibility and reactivity of coal blends and charcoal fines aiming use in ironmaking [PDF]

open access: yesMaterials Research, 2016
Charcoal is a very important reducing agent in Brazil, the world’s largest steel industry based on charcoal blast furnace. Charcoal generates large amounts of charcoal fines during its production and processing.
Claudia Caroline Teixeira Barbieri   +2 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Power of the informal: smallholder charcoal production in Mozambique [PDF]

open access: yes, 2017
The charcoal market in Africa is an informal economy. This enables millions of people to earn a living producing, selling and trading charcoal, due to low barriers to market entry.
Jones, Daniel Edward
core   +3 more sources

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

open access: yesAngewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha   +6 more
wiley   +2 more sources

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