Results 261 to 270 of about 47,101 (300)
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Charcot-Marie-Tooth Disease and Vincristine
Journal of the American Podiatric Medical Association, 2003This article reports on a case of sensorimotor neuropathy in a 55-year-old man that developed after vincristine therapy. Subsequent biopsy of the sural nerve and electromyographic studies revealed the presence of Charcot-Marie-Tooth disease. Only 17 patients who developed severe neuropathy with very low accumulated doses of vincristine have been ...
Javier Pascual-Huerta +2 more
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JAMA: The Journal of the American Medical Association, 1974
To the Editor.— Charcot-Marie-Tooth disease has traditionally been regarded as a pure neuropathic disease, and Siegel (228:873, 1974) suggested that the myopathic changes in two brothers with this disease could be caused by the neuropathy, in accordance with the "neurogenic hypothesis" of muscle disease.
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To the Editor.— Charcot-Marie-Tooth disease has traditionally been regarded as a pure neuropathic disease, and Siegel (228:873, 1974) suggested that the myopathic changes in two brothers with this disease could be caused by the neuropathy, in accordance with the "neurogenic hypothesis" of muscle disease.
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Axonal Charcot–Marie–Tooth disease
Current Opinion in Neurology, 2011The aim is to specify the genetic causes of dominantly and recessively inherited axonal forms of Charcot-Marie-Tooth disease (CMT) and review the biological basis for these disorders.More than 10 genes that cause axonal CMT have been identified over the past decade. Many of these genes express proteins that are ubiquitously expressed.
Agnes Patzko, Michael E. Shy
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2017
Charcot–Marie–Tooth disease (CMT) is most commonly encountered group of hereditary neuropathies which lead to slowly progressive muscle weakness and sensory loss. Symptoms emerge in a length-dependent manner. The group is classified on basis of the mode of inheritance and electrophysiological findings. Genetic testing confirms the diagnosis. Management
Bhagyadhan A. Patel +2 more
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Charcot–Marie–Tooth disease (CMT) is most commonly encountered group of hereditary neuropathies which lead to slowly progressive muscle weakness and sensory loss. Symptoms emerge in a length-dependent manner. The group is classified on basis of the mode of inheritance and electrophysiological findings. Genetic testing confirms the diagnosis. Management
Bhagyadhan A. Patel +2 more
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Pediatric Charcot-Marie-Tooth Disease
Pediatric Clinics of North America, 2015Heritable diseases of the peripheral nerves (Charcot-Marie-Tooth disease [CMT]) affect the motor units and sensory nerves, and they are among the most prevalent genetic conditions in the pediatric patient population. The typical clinical presentation includes distal muscle weakness and atrophy, but the severity and progression are largely variable ...
Gyula Acsadi +3 more
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The Hand in Charcot-Marie-Tooth Disease
Journal of Hand Surgery, 1991The upper extremity was evaluated in 68 symptomatic individuals previously diagnosed as having Charcot-Marie-Tooth disease. Consistent patterns of motor and sensory involvement were found noted as well as a predictable progression of neuromuscular deficits.
L. L. Williams +3 more
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The various Charcot–Marie–Tooth diseases
Current Opinion in Neurology, 2013This review focuses on recent advances in the diagnostic approaches and the underlying pathophysiological mechanisms of Charcot-Marie-Tooth (CMT) disease. We also discuss the emerging therapies for this hereditary neuropathy.To date, numerous genes are implicated in CMT, and new genes have recently been found to be associated with this neuropathy (INF2,
Jean-Michel Vallat +2 more
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SENSORY MANIFESTATIONS IN CHARCOT‐MARIE‐TOOTH DISEASE
Journal of the Peripheral Nervous System, 2000Although positive sensory symptoms are classically considered a hallmark of acquired neuropathies, sensory manifestations, in particular, pain, are not uncommon in Charcot‐Marie‐Tooth disease (CMT).We investigated the occurrence of sensory manifestations in 35 CMT patients (15 with CMT1, 20 with CMT2).Positive sensory manifestations were reported by 18
GEMIGNANI, Franco +4 more
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1996
The incidence of Charcot—Marie—Tooth disease is undetermined, but it is estimated that around 130 000 Europeans are affected. There are a number of variations of Charcot—Marie—Tooth disease in which deafness and kidney disease are more apparent, and these variations are thought probably to be more common than Charcot—Marie—Tooth without these aspects ...
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The incidence of Charcot—Marie—Tooth disease is undetermined, but it is estimated that around 130 000 Europeans are affected. There are a number of variations of Charcot—Marie—Tooth disease in which deafness and kidney disease are more apparent, and these variations are thought probably to be more common than Charcot—Marie—Tooth without these aspects ...
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Charcot-Marie-Tooth disease: an update
Current Opinion in Neurology, 2004The purpose of this review is to assist neurologists, neuroscientists and other interested readers in following the expanding volume of information relating to the inherited peripheral neuropathies collectively referred to as Charcot-Marie-Tooth disease.
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