Results 11 to 20 of about 87,063 (285)

Duration of total contact casting for resolution of acute Charcot foot: a retrospective cohort study

Journal of Foot and Ankle Research, 2021
Background Charcot neuroarthropathy (Charcot foot) is a highly destructive joint disease of the foot and ankle. If there is delayed diagnosis and treatment, it can lead to gross deformity, instability, recurrent ulceration and/or amputation.
Danielle A. Griffiths, Michelle R. Kaminski   +1 more
doaj   +2 more sources

Exploring Australian High-Risk Foot Podiatrists' Understanding of Recurrent and Contralateral Charcot Neuroarthropathy in Individuals With Diabetes Mellitus: A Qualitative Study. [PDF]

J Foot Ankle Res
ABSTRACT Introduction Charcot neuroarthropathy (CN) can result in severe destruction of the foot and the ankle. Additional episodes of acute CN in the same or contralateral foot cause additional burden. This study aimed to explore Australian high‐risk foot podiatrists' understanding of recurrent and contralateral CN in individuals with diabetes ...
Cheong KY, Landorf KB, Munteanu SE, Bergin SM.   +3 more
europepmc   +2 more sources

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

Molecules, 2018
Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and blood vessels. The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia ...
Jiyong Su
doaj   +2 more sources

Novel Biallelic PLEKHG5 Variant Associated With Intermediate Charcot-Marie-Tooth Disease: Case Report From South America. [PDF]

J Peripher Nerv Syst
ABSTRACT Background and Aims Biallelic pathogenic variants in PLEKHG5 are associated with two distinct recessive phenotypes, including distal hereditary motor neuropathy AR type 4 and intermediate Charcot‐Marie‐Tooth disease type C (CMT). No South American cases have been previously reported.
Vidon RO, Tomaselli PJ, Bittar-Braune C, Pitta IJ, de Lacerda GCB, Jardim M.   +5 more
europepmc   +2 more sources

Guidelines on the diagnosis and treatment of active Charcot neuro‐osteoarthropathy in persons with diabetes mellitus (IWGDF 2023)

Diabetes/Metabolism Research Reviews, 2023
The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999.
D. Wukich, N. Schaper, C. Gooday, A. Bal, R. Bém, A. Chhabra, M. Hastings, Crystal Holmes, N. Petrova, M. G. Santini Araujo, É. Senneville, Katherine M Raspovic   +11 more
semanticscholar   +1 more source

Misregulation of mitochondria–lysosome contact dynamics in Charcot–Marie–Tooth Type 2B disease Rab7 mutant sensory peripheral neurons

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Charcot–Marie–Tooth disease is the most common genetic peripheral neuropathy, with autosomal dominant mutations in Rab7 causing Charcot–Marie–Tooth type 2B disease, which is characterized by the axonal degeneration of peripheral sensory ...
Y. Wong, Nirupa D. Jayaraj, Tayler B. Belton, George C Shum, Hannah E Ball, D. Ren, A. Tadenev, D. Krainc, R. W. Burgess, D. Menichella   +9 more
semanticscholar   +1 more source

Charcot Neuroarthropathy: Current Surgical Management and Update. A Systematic Review

Frontiers in Surgery, 2022
Background Charcot neuroarthropathy of the ankle and the hindfoot is a complex clinical entity with a high risk of amputation. Charcot neuroarthropathy limb reconstruction has been proposed as a limb-salvaging procedure.
M. Y. Bajuri, Shir Lee Ong, Srijit Das, I. Mohamed   +3 more
semanticscholar   +1 more source

Emerging Therapies for Charcot-Marie-Tooth Inherited Neuropathies

International Journal of Molecular Sciences, 2021
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically heterogeneous disorders affecting the peripheral nerves, causing significant and slowly progressive disability over the lifespan.
Marina Stavrou, I. Sargiannidou, E. Georgiou, A. Kagiava, K. Kleopa   +4 more
semanticscholar   +1 more source

Broadening the Clinical Spectrum of Axonal Hereditary Neuropathies: A Comparative Case Study on DNAJB2- and HINT1-Related Disease. [PDF]

J Peripher Nerv Syst
ABSTRACT Background and Aims Differentiating hereditary axonal polyneuropathies caused by distinct gene variants remains a clinical challenge. This comparative case study of DNAJB2‐ and HINT1‐related neuropathies aimed to broaden the phenotypic spectrum associated with these genes and to explore non‐motor symptoms and quality of life (QoL) in affected ...
Bjelica B, Hendrich C, von Hardenberg S, Vukojevic M, Körner S, Gschwendtberger T, Haghikia A, Peric S, Petri S.   +8 more
europepmc   +2 more sources

How Common Is the Rare Charcot Foot in Patients With Diabetes?

Diabetes Care, 2021
The Charcot foot is a devastating complication to diabetes (1). It manifests as an acute aseptic inflammation of bones and joints in the feet. If not diagnosed and treated in time, it may lead to collapse of bones in the foot, which causes deformity ...
O. Svendsen, Oliver Christian Rabe, M. Winther-Jensen, Kristine Højgaard Allin   +3 more
semanticscholar   +1 more source