Results 41 to 50 of about 124,447 (265)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Understanding charge radii with machine learning: Discovering physics expressions

Physics Letters B
We introduce a robust, interpretable machine learning (ML) framework that combines numerical regression for high-accuracy predictions with symbolic regression to uncover the underlying physics.
B. Maheshwari, P. Van Isacker
doaj   +1 more source

Charges from Dressed Matter: Physics and Renormalisation [PDF]

Annals of Physics, 2000
Gauge theories are characterised by long range interactions. Neglecting these interactions at large times, and identifying the Lagrangian matter fields with the asymptotic physical fields, leads to the infra-red problem. In this paper we study the perturbative applications of a construction of physical charges in QED, where the matter fields are ...
Bagan, Emili, Lavelle, Martin, McMullan, David   +2 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Probing new physics with charge asymmetries in 2 same-sign leptons plus jets final states at the LHC

Journal of High Energy Physics
We study the impact of new physics models in the charge asymmetry defined for LHC final states consisting of two same-sign leptons (2SSl, with l = e, μ) plus jets (N jets ≥ 2), with a center-of-mass energy of s $$ \sqrt{s} $$ = 13 TeV, where the main SM ...
Ernesto Arganda, Leandro Da Rold, Aurelio Juste, Anibal D. Medina, Rosa M. Sandá Seoane   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Physics of High-Charge Electron Beams in Laser-Plasma Wakefields

Physical Review X, 2020
Laser wakefield acceleration (LWFA) and its particle-driven counterpart, particle or plasma wakefield acceleration (PWFA), are commonly treated as separate, though related, branches of high-gradient plasma-based acceleration.
J. Götzfried, A. Döpp, M. F. Gilljohann, F. M. Foerster, H. Ding, S. Schindler, G. Schilling, A. Buck, L. Veisz, S. Karsch   +9 more
doaj   +1 more source

Reflections on Physics Education and Communication with Tibetan Monastics

Frontiers in Communication, 2021
Physics education research, a field that is now over 100 years old, has made it clear: the key to teaching physics successfully is to prioritize getting the concepts across, and the mathematical representation (“laws”) can come later.
Judith Beck, Justin C. Burton, Martin Kamela, Michelle P. Kuchera, Amy J. Lovell, Kerstin Nordstrom, Thinley Tenzin, Julie Ziffer   +7 more
doaj   +1 more source

Conformal collider physics: energy and charge correlations [PDF]

Journal of High Energy Physics, 2008
We study observables in a conformal field theory which are very closely related to the ones used to describe hadronic events at colliders. We focus on the correlation functions of the energies deposited on calorimeters placed at a large distance from the collision.
Hofman, Diego M., Maldacena, Juan
openaire   +2 more sources

Physical mechanisms of photoinduced charge transfer in neutral and charged donor–acceptor systems

RSC Advances, 2021
In this paper, we provide visualization methods to reveal the physical mechanisms of photoinduced charge transfer in neutral and charged donor–acceptor systems.
Chunhua Tian, Yichuan Chen, Pen-ji Yan, Mengtao Sun, Jun Quan   +4 more
openaire   +3 more sources