Results 31 to 40 of about 18,047 (254)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An 8.72 µW Low-Noise and Wide Bandwidth FEE Design for High-Throughput Pixel-Strip (PS) Sensors

Sensors, 2021
The front-end electronics (FEE) of the Compact Muon Solenoid (CMS) is needed very low power consumption and higher readout bandwidth to match the low power requirement of its Short Strip application-specific integrated circuits (ASIC) (SSA) and to handle
Folla Kamdem Jérôme, Wembe Tafo Evariste, Essimbi Zobo Bernard, Maria Liz Crespo, Andres Cicuttin, Mamun Bin Ibne Reaz, Mohammad Arif Sobhan Bhuiyan   +6 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

LNSTRIP read-out ASIC for the X-ray strip detectors [PDF]

International Journal of Electronics and Telecommunications
The X-ray imaging systems dedicated for X-ray spectroscopy, based on a semiconductor strip sensors have been recently an important research topic. The most important research objective is working towards improvement of the spectroscopic and position ...
Weronika Zubrzycka-Singh
doaj   +1 more source

Design of a charge sensitive spectroscopy amplifier for Compton camera

Journal of Physics: Conference Series, 2017
A charge sensitive spectroscopy amplifier has been designed to couple with the silicon strip detector of a Compton camera. The amplifier was optimized by using a wave form generator and the output gain of 1012V/C was achieved when the shaping time is 1μs.
Wei Wang, Junliang Liu, Deyang Yu, Xin Li, Xiaohong Cai   +4 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Simulation study on time resolution optimization of silicon drift detector

He jishu, 2021
BackgroundThe silicon drift detector (SDD) has been widely used in space exploration in recent years. The SDD has outstanding energy resolution, but its time resolution is not very satisfactory.
YU Nian, XU Yupeng, CAI Yanke, ZHU Yuxuan, ZHAO Xiaofan, CHEN Can   +5 more
doaj   +1 more source

Charge-Sensitive Poly-Silicon TFT Amplifiers for a-Si:H Pixel Particle Detectors [PDF]

MRS Proceedings, 1992
ABSTRACTPrototype charge-sensitive poly-Si TFT amplifiers have been made for the amplification of signals (from an a-Si:H pixel diode used as an ionizing particle detector). They consist of a charge-sensitive gain stage, a voltage gain stage and a source follower output stage. The gain-bandwidth product of the amplifier is ∼ 300 MHz. When the amplifier
Cho, G., Perez-Mendez, V., Mack, M., Lewis, A.   +3 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Design of CMOS Charge-sensitive Amplifier for Coaxial High Purity Germanium Detector

Yuanzineng kexue jishu
High purity germanium detectors play an increasingly significant role in particle physics and astrophysics, particularly in low-background radiation measurement experiments, due to their exceptional energy resolution, high detection efficiency.
LIU Zhan, HE Gaokui, LIU Haifeng
doaj   +1 more source