Results 61 to 70 of about 290,004 (269)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Charge transport scaling in turbulent electroconvection [PDF]
Physical Review E, 2005 12 pages, 7 figures, Submitted to Phys. Rev. E.
Tsai, Peichun +2 more
openaire +4 more sources
Low bias charge transport in DNA
Scientific ReportsThe low-bias current–voltage technique was utilized to study charge transport in single-stranded DNA (ssDNA), assessing the method’s effectiveness for future studies aimed at estimating the degree of mutation or DNA damage.
Maciej Wiesner +5 more
doaj +1 more source
Charge transport in organic nanocrystal diodes based on rolled-up robust nanomembrane contacts
Beilstein Journal of Nanotechnology, 2017 The investigation of charge transport in organic nanocrystals is essential to understand nanoscale physical properties of organic systems and the development of novel organic nanodevices. In this work, we fabricate organic nanocrystal diodes contacted by
Vineeth Kumar Bandari +7 more
doaj +1 more source
Ambipolar charge transport in a non-fullerene acceptor
APL Materials, 2023 Charge transport is one of the key factors in the operation of organic solar cells. Here, we investigate the electron and hole transport in the non-fullerene acceptor (NFA) IT-4F, by a combination of space-charge-limited current measurements and ...
Franziska H. Hasenburg +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
InfoMatOutstanding charge transport in molecular crystals is of great importance in modern electronics and optoelectronics. The widely adopted strategies to enhance charge transport, such as restraining intermolecular vibration, are mostly limited to organic ...
Jie Wu +12 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Oxidation States, Thouless’ Pumps, and Nontrivial Ionic Transport in Nonstoichiometric Electrolytes
Physical Review X, 2020 Thouless’ quantization of adiabatic particle transport permits one to associate an integer topological charge with each atom of an electronically gapped material.
Paolo Pegolo +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source