Results 151 to 160 of about 915,738 (325)
Living at genetic risk: The patient experience of Lynch syndrome
International Journal of Cancer, EarlyView.Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents +2 more
wiley +1 more source
Outcomes from the English National Lynch Syndrome transformation project
International Journal of Cancer, EarlyView.What's New? The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation Project in England aims to ensure that patients newly diagnosed with colorectal or endometrial cancer are offered testing for the syndrome ...
Kevin J. Monahan +16 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? The DNA methylation‐based WID‐qEC test has been validated for the accurate detection of endometrial and cervical cancers using cervico‐vaginal samples. However, a small proportion of women test positive despite the absence of these cancers. This study explored the associated biological and clinical characteristics to inform potential follow‐
Elisa Redl +18 more
wiley +1 more source
Positive Freedom and the Social Meaning of Money
Journal of Applied Philosophy, EarlyView.ABSTRACT Semiotic objections to markets hold that buying and selling certain things – for example, sex, body parts, votes, surrogacy services – expresses that those things are fungible with money, which has only profane value. This article offers a more fundamental challenge to semiotic critiques of market.
Andrew Allison +2 more
wiley +1 more source
Journal of Clinical Psychology, Volume 81, Issue 6, Page 526-537, June 2025.ABSTRACT Deliberate Practice (DP) is a model of behavioral skill acquisition structured by several key tasks. The past decade has shown a consistent growth in interest in this form of learning for psychotherapy skills, with promising research suggesting DP training is superior to traditional learning methods of psychotherapy. This paper presents a case
Dan Sacks
wiley +1 more source
JCPP Advances, EarlyView.We examined the efficacy of an online growth mindset single session intervention (SSI) for young people aged 14–18 years old in the UK. 104 participants were randomised to a registered clinical trial. Intention‐to‐treat analysis yielded negligible effect sizes for anxiety and depression symptoms, whereas the effect on personality mindset was ...
Jessica Ball +7 more
wiley +1 more source
JCPP Advances, EarlyView.Abstract Background Adolescents who have had an acquired brain injury (ABI) commonly experience depression. Brief Behavioural Activation (Brief BA) is a successful, values‐based intervention for managing depression in neurotypical adolescents. This study investigated the effectiveness of Brief BA, using a single‐case experimental design, with ...
Conor R. O’Brien +4 more
wiley +1 more source
JCPP Advances, EarlyView.In our project to develop a digital tool for counterfactual analysis, with an emphasis on researching active ingredients for adolescent mental health, we incorporated lived experience expertise across the lifecycle of tool development and dissemination.
Marie Allitt +3 more
wiley +1 more source
JCPP Advances, EarlyView.Abstract Background Accounts of emotional dysregulation in autism and attention‐deficit/hyperactivity disorder (ADHD) are typically based on external adult observations anchored in neurotypical notions of emotional responding. These often fail to place neurodivergent people's emotional responses in the context of the upsetting experiences they face ...
Georgia Pavlopoulou +53 more
wiley +1 more source